JNK(1/2) represses Lkb(1)-deficiency-induced lung squamous cell carcinoma progression

Mechanisms of lung squamous cell carcinoma (LSCC) development are poorly understood. Here, we report that JNK1/2 activities attenuate Lkb1-deficiency-driven LSCC initiation and progression through repressing ΔNp63 signaling. In vivo Lkb1 ablation alone is sufficient to induce LSCC development by red...

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Detalles Bibliográficos
Autores principales: Liu, Jian, Wang, Tianyuan, Creighton, Chad J., Wu, San-Pin, Ray, Madhumita, Janardhan, Kyathanahalli S., Willson, Cynthia J., Cho, Sung-Nam, Castro, Patricia D., Ittmann, Michael M., Li, Jian-Liang, Davis, Roger J., DeMayo, Francesco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517592/
https://www.ncbi.nlm.nih.gov/pubmed/31089135
http://dx.doi.org/10.1038/s41467-019-09843-1

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