Transcriptional Suppression of CPI-17 Gene Expression in Vascular Smooth Muscle Cells by Tumor Necrosis Factor, Krüppel-Like Factor 4, and Sp1 Is Associated with Lipopolysaccharide-Induced Vascular Hypocontractility, Hypotension, and Mortality

Vasodilatory shock in sepsis is caused by the failure of the vasculature to respond to vasopressors, which results in hypotension, multiorgan failure, and ultimately patient death. Recently, it was reported that CPI-17, a key player in the regulation of smooth muscle contraction, was downregulated b...

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Detalles Bibliográficos
Autores principales: Zhao, Guogang, Zhong, Yu, Su, Wen, Liu, Shu, Song, Xiulong, Hou, Tianfei, Mu, Xufang, Gong, Ming Cui, Guo, Zhenheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517596/
https://www.ncbi.nlm.nih.gov/pubmed/30936247
http://dx.doi.org/10.1128/MCB.00070-19

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