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Does experienced pain affects local brain volumes? Insights from a clinical acute pain model
Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcorti...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Asociacion Espanola de Psicologia Conductual
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517646/ https://www.ncbi.nlm.nih.gov/pubmed/31193130 http://dx.doi.org/10.1016/j.ijchp.2019.01.001 |
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author | Torrecillas-Martínez, Laura Catena, Andrés O’Valle, Francisco Padial-Molina, Miguel Galindo-Moreno, Pablo |
author_facet | Torrecillas-Martínez, Laura Catena, Andrés O’Valle, Francisco Padial-Molina, Miguel Galindo-Moreno, Pablo |
author_sort | Torrecillas-Martínez, Laura |
collection | PubMed |
description | Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage. |
format | Online Article Text |
id | pubmed-6517646 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Asociacion Espanola de Psicologia Conductual |
record_format | MEDLINE/PubMed |
spelling | pubmed-65176462019-05-28 Does experienced pain affects local brain volumes? Insights from a clinical acute pain model Torrecillas-Martínez, Laura Catena, Andrés O’Valle, Francisco Padial-Molina, Miguel Galindo-Moreno, Pablo Int J Clin Health Psychol Originals article Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage. Asociacion Espanola de Psicologia Conductual 2019-05 2019-03-04 /pmc/articles/PMC6517646/ /pubmed/31193130 http://dx.doi.org/10.1016/j.ijchp.2019.01.001 Text en © 2019 Asociación Española de Psicología Conductual. Published by Elsevier España, S.L.U. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Originals article Torrecillas-Martínez, Laura Catena, Andrés O’Valle, Francisco Padial-Molina, Miguel Galindo-Moreno, Pablo Does experienced pain affects local brain volumes? Insights from a clinical acute pain model |
title | Does experienced pain affects local brain volumes? Insights from a clinical acute pain model |
title_full | Does experienced pain affects local brain volumes? Insights from a clinical acute pain model |
title_fullStr | Does experienced pain affects local brain volumes? Insights from a clinical acute pain model |
title_full_unstemmed | Does experienced pain affects local brain volumes? Insights from a clinical acute pain model |
title_short | Does experienced pain affects local brain volumes? Insights from a clinical acute pain model |
title_sort | does experienced pain affects local brain volumes? insights from a clinical acute pain model |
topic | Originals article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517646/ https://www.ncbi.nlm.nih.gov/pubmed/31193130 http://dx.doi.org/10.1016/j.ijchp.2019.01.001 |
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