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Does experienced pain affects local brain volumes? Insights from a clinical acute pain model

Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcorti...

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Autores principales: Torrecillas-Martínez, Laura, Catena, Andrés, O’Valle, Francisco, Padial-Molina, Miguel, Galindo-Moreno, Pablo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Asociacion Espanola de Psicologia Conductual 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517646/
https://www.ncbi.nlm.nih.gov/pubmed/31193130
http://dx.doi.org/10.1016/j.ijchp.2019.01.001
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author Torrecillas-Martínez, Laura
Catena, Andrés
O’Valle, Francisco
Padial-Molina, Miguel
Galindo-Moreno, Pablo
author_facet Torrecillas-Martínez, Laura
Catena, Andrés
O’Valle, Francisco
Padial-Molina, Miguel
Galindo-Moreno, Pablo
author_sort Torrecillas-Martínez, Laura
collection PubMed
description Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage.
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spelling pubmed-65176462019-05-28 Does experienced pain affects local brain volumes? Insights from a clinical acute pain model Torrecillas-Martínez, Laura Catena, Andrés O’Valle, Francisco Padial-Molina, Miguel Galindo-Moreno, Pablo Int J Clin Health Psychol Originals article Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analyses were done using multiple regression, being pain scores the predictors and voxel volumes, subcortical nuclei volumes and subcortical nuclei shapes, the outcomes. Results:Pain was significantly larger at pain than at anesthesia and analgesia stages, and was higher during anesthesia than during analgesia. Pain intensity was related to grey matter in several cortical (Insula, Mid Frontal and Temporal Gyruses, Precuneus, Anterior Cingulate), and subcortical nuclei (Hippocampus, Thalamus, Putamen, Amygdala), depending of the post-surgical stage. A larger number of brain areas showed significance at pain that at anesthesia and analgesia stages. Conclusions:The relationships of regional brain volumes and subcortical nuclei shapes with pain scores seemed to be unsteady, as they changed with the patient's actual pain stage. Asociacion Espanola de Psicologia Conductual 2019-05 2019-03-04 /pmc/articles/PMC6517646/ /pubmed/31193130 http://dx.doi.org/10.1016/j.ijchp.2019.01.001 Text en © 2019 Asociación Española de Psicología Conductual. Published by Elsevier España, S.L.U. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Originals article
Torrecillas-Martínez, Laura
Catena, Andrés
O’Valle, Francisco
Padial-Molina, Miguel
Galindo-Moreno, Pablo
Does experienced pain affects local brain volumes? Insights from a clinical acute pain model
title Does experienced pain affects local brain volumes? Insights from a clinical acute pain model
title_full Does experienced pain affects local brain volumes? Insights from a clinical acute pain model
title_fullStr Does experienced pain affects local brain volumes? Insights from a clinical acute pain model
title_full_unstemmed Does experienced pain affects local brain volumes? Insights from a clinical acute pain model
title_short Does experienced pain affects local brain volumes? Insights from a clinical acute pain model
title_sort does experienced pain affects local brain volumes? insights from a clinical acute pain model
topic Originals article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517646/
https://www.ncbi.nlm.nih.gov/pubmed/31193130
http://dx.doi.org/10.1016/j.ijchp.2019.01.001
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