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Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases
Momordica charantia, commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its pharmacological activities, and nutritional properties. Due to the presence of many bioactive compounds, some of which possess potent biological actions, this plant is used in...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517695/ https://www.ncbi.nlm.nih.gov/pubmed/31139079 http://dx.doi.org/10.3389/fphar.2019.00486 |
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author | Bortolotti, Massimo Mercatelli, Daniele Polito, Letizia |
author_facet | Bortolotti, Massimo Mercatelli, Daniele Polito, Letizia |
author_sort | Bortolotti, Massimo |
collection | PubMed |
description | Momordica charantia, commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its pharmacological activities, and nutritional properties. Due to the presence of many bioactive compounds, some of which possess potent biological actions, this plant is used in folk medicine all over the world for the treatment of different pathologies, mainly diabetes, but also cancer, and other inflammation-associated diseases. It is widely demonstrated that M. charantia extracts contribute in lowering glycaemia in patients affected by type 2 diabetes. However, the majority of existing studies on M. charantia bioactive compounds were performed only on cell lines and in animal models. Therefore, because the real impact of bitter melon on human health has not been thoroughly demonstrated, systematic clinical studies are needed to establish its efficacy and safety in patients. Besides, both in vitro and in vivo studies have demonstrated that bitter melon may also elicit toxic or adverse effects under different conditions. The aim of this review is to provide an overview of anti-inflammatory and anti-neoplastic properties of bitter melon, discussing its pharmacological activity as well as the potential adverse effects. Even if a lot of literature is available about bitter melon as antidiabetic drug, few papers discuss the anti-inflammatory and anti-cancer properties of this plant. |
format | Online Article Text |
id | pubmed-6517695 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-65176952019-05-28 Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases Bortolotti, Massimo Mercatelli, Daniele Polito, Letizia Front Pharmacol Pharmacology Momordica charantia, commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its pharmacological activities, and nutritional properties. Due to the presence of many bioactive compounds, some of which possess potent biological actions, this plant is used in folk medicine all over the world for the treatment of different pathologies, mainly diabetes, but also cancer, and other inflammation-associated diseases. It is widely demonstrated that M. charantia extracts contribute in lowering glycaemia in patients affected by type 2 diabetes. However, the majority of existing studies on M. charantia bioactive compounds were performed only on cell lines and in animal models. Therefore, because the real impact of bitter melon on human health has not been thoroughly demonstrated, systematic clinical studies are needed to establish its efficacy and safety in patients. Besides, both in vitro and in vivo studies have demonstrated that bitter melon may also elicit toxic or adverse effects under different conditions. The aim of this review is to provide an overview of anti-inflammatory and anti-neoplastic properties of bitter melon, discussing its pharmacological activity as well as the potential adverse effects. Even if a lot of literature is available about bitter melon as antidiabetic drug, few papers discuss the anti-inflammatory and anti-cancer properties of this plant. Frontiers Media S.A. 2019-05-08 /pmc/articles/PMC6517695/ /pubmed/31139079 http://dx.doi.org/10.3389/fphar.2019.00486 Text en Copyright © 2019 Bortolotti, Mercatelli and Polito. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pharmacology Bortolotti, Massimo Mercatelli, Daniele Polito, Letizia Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases |
title | Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases |
title_full | Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases |
title_fullStr | Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases |
title_full_unstemmed | Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases |
title_short | Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases |
title_sort | momordica charantia, a nutraceutical approach for inflammatory related diseases |
topic | Pharmacology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6517695/ https://www.ncbi.nlm.nih.gov/pubmed/31139079 http://dx.doi.org/10.3389/fphar.2019.00486 |
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