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Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy

We aimed to explore left atrial (LA) remodeling in the patients with solid cancer before initiation of chemo- or radiotherapy. This retrospective investigation included 92 chemo- and radiotherapy-naive cancer patients and 40 age- and gender-matched controls with a similar cardiovascular risk profile...

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Autores principales: Tadic, Marijana, Genger, Martin, Cuspidi, Cesare, Belyavskiy, Evgeny, Frydas, Athanasios, Dordevic, Aleksandar, Morris, Daniel A., Völkl, Jakob, Parwani, Abdul Shokor, Pieske, Burkert, Haßfeld, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518037/
https://www.ncbi.nlm.nih.gov/pubmed/30934794
http://dx.doi.org/10.3390/jcm8040421
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author Tadic, Marijana
Genger, Martin
Cuspidi, Cesare
Belyavskiy, Evgeny
Frydas, Athanasios
Dordevic, Aleksandar
Morris, Daniel A.
Völkl, Jakob
Parwani, Abdul Shokor
Pieske, Burkert
Haßfeld, Sabine
author_facet Tadic, Marijana
Genger, Martin
Cuspidi, Cesare
Belyavskiy, Evgeny
Frydas, Athanasios
Dordevic, Aleksandar
Morris, Daniel A.
Völkl, Jakob
Parwani, Abdul Shokor
Pieske, Burkert
Haßfeld, Sabine
author_sort Tadic, Marijana
collection PubMed
description We aimed to explore left atrial (LA) remodeling in the patients with solid cancer before initiation of chemo- or radiotherapy. This retrospective investigation included 92 chemo- and radiotherapy-naive cancer patients and 40 age- and gender-matched controls with a similar cardiovascular risk profile as the cancer group. All participants underwent comprehensive echocardiographic examination before the start of chemo- or radiotherapy. LA phasic function was evaluated in volumetric and strain method. Indexed minimal and pre-A LA volumes were significantly higher in the cancer patients. Total and passive LA emptying fraction (EF) were significantly lower, whereas active LAEF was significantly higher in the cancer patients. LA total longitudinal strain was significantly lower in the cancer patients. Strain rate analysis of LA phasic function showed that LA function during systole and early diastole was reduced in the cancer group, while it was increased during late diastole. These findings indicated that LA reservoir and conduit functions, assessed with LA volumetric and strain analysis, were deteriorated in the cancer group. On the other hand, LA booster pump function was elevated in the cancer group in comparison with the controls. In the whole population, cancer was associated with reduced LA total longitudinal strain independently of age, gender, BMI, LV hypertrophy, E/e’ ratio, diabetes, and hypertension. LA phasic function was impaired in the chemo- and radiotherapy-naive cancer patients in comparison with the control group. Cancer, LV hypertrophy, and hypertension were associated with reduced LA longitudinal strain independently of other important clinical parameters.
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spelling pubmed-65180372019-05-31 Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy Tadic, Marijana Genger, Martin Cuspidi, Cesare Belyavskiy, Evgeny Frydas, Athanasios Dordevic, Aleksandar Morris, Daniel A. Völkl, Jakob Parwani, Abdul Shokor Pieske, Burkert Haßfeld, Sabine J Clin Med Article We aimed to explore left atrial (LA) remodeling in the patients with solid cancer before initiation of chemo- or radiotherapy. This retrospective investigation included 92 chemo- and radiotherapy-naive cancer patients and 40 age- and gender-matched controls with a similar cardiovascular risk profile as the cancer group. All participants underwent comprehensive echocardiographic examination before the start of chemo- or radiotherapy. LA phasic function was evaluated in volumetric and strain method. Indexed minimal and pre-A LA volumes were significantly higher in the cancer patients. Total and passive LA emptying fraction (EF) were significantly lower, whereas active LAEF was significantly higher in the cancer patients. LA total longitudinal strain was significantly lower in the cancer patients. Strain rate analysis of LA phasic function showed that LA function during systole and early diastole was reduced in the cancer group, while it was increased during late diastole. These findings indicated that LA reservoir and conduit functions, assessed with LA volumetric and strain analysis, were deteriorated in the cancer group. On the other hand, LA booster pump function was elevated in the cancer group in comparison with the controls. In the whole population, cancer was associated with reduced LA total longitudinal strain independently of age, gender, BMI, LV hypertrophy, E/e’ ratio, diabetes, and hypertension. LA phasic function was impaired in the chemo- and radiotherapy-naive cancer patients in comparison with the control group. Cancer, LV hypertrophy, and hypertension were associated with reduced LA longitudinal strain independently of other important clinical parameters. MDPI 2019-03-27 /pmc/articles/PMC6518037/ /pubmed/30934794 http://dx.doi.org/10.3390/jcm8040421 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tadic, Marijana
Genger, Martin
Cuspidi, Cesare
Belyavskiy, Evgeny
Frydas, Athanasios
Dordevic, Aleksandar
Morris, Daniel A.
Völkl, Jakob
Parwani, Abdul Shokor
Pieske, Burkert
Haßfeld, Sabine
Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy
title Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy
title_full Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy
title_fullStr Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy
title_full_unstemmed Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy
title_short Phasic Left Atrial Function in Cancer Patients Before Initiation of Anti-Cancer Therapy
title_sort phasic left atrial function in cancer patients before initiation of anti-cancer therapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518037/
https://www.ncbi.nlm.nih.gov/pubmed/30934794
http://dx.doi.org/10.3390/jcm8040421
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