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Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults

Emerging evidence suggests a role for the gut microbiota in glucose metabolism and diabetes. Few studies have examined the associations between the faecal microbiome and insulin sensitivity and secretion using gold-standard methods in high-risk populations prior to diabetes onset. We investigated th...

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Autores principales: Naderpoor, Negar, Mousa, Aya, Gomez-Arango, Luisa F., Barrett, Helen L., Dekker Nitert, Marloes, de Courten, Barbora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518043/
https://www.ncbi.nlm.nih.gov/pubmed/30987356
http://dx.doi.org/10.3390/jcm8040452
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author Naderpoor, Negar
Mousa, Aya
Gomez-Arango, Luisa F.
Barrett, Helen L.
Dekker Nitert, Marloes
de Courten, Barbora
author_facet Naderpoor, Negar
Mousa, Aya
Gomez-Arango, Luisa F.
Barrett, Helen L.
Dekker Nitert, Marloes
de Courten, Barbora
author_sort Naderpoor, Negar
collection PubMed
description Emerging evidence suggests a role for the gut microbiota in glucose metabolism and diabetes. Few studies have examined the associations between the faecal microbiome and insulin sensitivity and secretion using gold-standard methods in high-risk populations prior to diabetes onset. We investigated the relationships between faecal microbiota composition (16S rRNA sequencing) and gold-standard measures of insulin sensitivity (hyperinsulinaemic-euglycaemic clamp) and insulin secretion (intravenous glucose tolerance test) in 38 overweight or obese otherwise healthy individuals. Genus Clostridium was positively associated with insulin sensitivity, and genera Dialister and Phascolarctobacterium were related to both insulin sensitivity and secretion. Insulin sensitivity was associated with a higher abundance of Phascolarctobacterium and lower abundance of Dialister. Those with higher insulin secretion had a higher abundance of Dialister and lower abundance of Bifidobacterium, compared to those with lower insulin secretion. Body mass index (BMI) was positively correlated with Streptococcus abundance whereas Coprococcus abundance was negatively correlated to BMI and percent body fat. These results suggest that faecal microbiota is related to insulin sensitivity and secretion in overweight or obese adults. These correlations are distinct although partially overlapping, suggesting different pathophysiological pathways. Our findings can inform future trials aiming to manipulate gut microbiome to improve insulin sensitivity and secretion and prevent type 2 diabetes.
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spelling pubmed-65180432019-05-31 Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults Naderpoor, Negar Mousa, Aya Gomez-Arango, Luisa F. Barrett, Helen L. Dekker Nitert, Marloes de Courten, Barbora J Clin Med Article Emerging evidence suggests a role for the gut microbiota in glucose metabolism and diabetes. Few studies have examined the associations between the faecal microbiome and insulin sensitivity and secretion using gold-standard methods in high-risk populations prior to diabetes onset. We investigated the relationships between faecal microbiota composition (16S rRNA sequencing) and gold-standard measures of insulin sensitivity (hyperinsulinaemic-euglycaemic clamp) and insulin secretion (intravenous glucose tolerance test) in 38 overweight or obese otherwise healthy individuals. Genus Clostridium was positively associated with insulin sensitivity, and genera Dialister and Phascolarctobacterium were related to both insulin sensitivity and secretion. Insulin sensitivity was associated with a higher abundance of Phascolarctobacterium and lower abundance of Dialister. Those with higher insulin secretion had a higher abundance of Dialister and lower abundance of Bifidobacterium, compared to those with lower insulin secretion. Body mass index (BMI) was positively correlated with Streptococcus abundance whereas Coprococcus abundance was negatively correlated to BMI and percent body fat. These results suggest that faecal microbiota is related to insulin sensitivity and secretion in overweight or obese adults. These correlations are distinct although partially overlapping, suggesting different pathophysiological pathways. Our findings can inform future trials aiming to manipulate gut microbiome to improve insulin sensitivity and secretion and prevent type 2 diabetes. MDPI 2019-04-04 /pmc/articles/PMC6518043/ /pubmed/30987356 http://dx.doi.org/10.3390/jcm8040452 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Naderpoor, Negar
Mousa, Aya
Gomez-Arango, Luisa F.
Barrett, Helen L.
Dekker Nitert, Marloes
de Courten, Barbora
Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults
title Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults
title_full Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults
title_fullStr Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults
title_full_unstemmed Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults
title_short Faecal Microbiota Are Related to Insulin Sensitivity and Secretion in Overweight or Obese Adults
title_sort faecal microbiota are related to insulin sensitivity and secretion in overweight or obese adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518043/
https://www.ncbi.nlm.nih.gov/pubmed/30987356
http://dx.doi.org/10.3390/jcm8040452
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