Cargando…

Mismatch Repair/Microsatellite Instability Testing Practices among US Physicians Treating Patients with Advanced/Metastatic Colorectal Cancer

The study objective was to assess US physicians’ Mismatch Repair/Microsatellite Instability (MMR/MSI) testing practices for metastatic colorectal cancer (mCRC) patients. A non-interventional, cross-sectional online survey was conducted among 151 physicians (91 oncologists, 15 surgeons and 45 patholo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Eriksson, Jennifer, Amonkar, Mayur, Al-Jassar, Gemma, Lambert, Jeremy, Malmenäs, Mia, Chase, Monica, Sun, Lucy, Kollmar, Linda, Vichnin, Michelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518162/ https://www.ncbi.nlm.nih.gov/pubmed/31022981 http://dx.doi.org/10.3390/jcm8040558

Ejemplares similares

Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency
por: Cohen, Romain, et al.
Publicado: (2021)

Gynecological Cancers Caused by Deficient Mismatch Repair and Microsatellite Instability
por: Deshpande, Madhura, et al.
Publicado: (2020)

Advances in immune therapies for the treatment of microsatellite instability-high/deficient mismatch repair metastatic colorectal cancer (Review)
por: Choucair, Khalil, et al.
Publicado: (2021)

Microsatellite Instability Use in Mismatch Repair Gene Sequence Variant Classification
por: Thompson, Bryony A., et al.
Publicado: (2015)

Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs
por: Inanaga, Sakuya, et al.
Publicado: (2022)

The degree of microsatellite instability predicts response to PD-1 blockade immunotherapy in mismatch repair-deficient/microsatellite instability-high colorectal cancers
por: Wang, Qiao-Xuan, et al.
Publicado: (2021)

Genomic Profiling for KRAS, NRAS, BRAF, Microsatellite Instability, and Mismatch Repair Deficiency Among Patients With Metastatic Colon Cancer
por: Gutierrez, Martin E., et al.
Publicado: (2019)

Non-classical phenotypes of mismatch repair deficiency and microsatellite instability in primary and metastatic tumors at different sites in Lynch syndrome
por: Li, Zhiyu, et al.
Publicado: (2022)

Microsatellite instability and mismatch repair gene inactivation in sporadic pancreatic and colon tumours
por: Ghimenti, C, et al.
Publicado: (1999)

Microsatellite instability and mismatch repair protein expressions in lymphocyte‐predominant breast cancer
por: Horimoto, Yoshiya, et al.
Publicado: (2020)

Mismatch Repair Protein Expression and Microsatellite Instability in Cutaneous Squamous Cell Carcinoma
por: Gambichler, Thilo, et al.
Publicado: (2021)

Mismatch repair is a double-edged sword in the battle against microsatellite instability
por: Miller, Carson J., et al.
Publicado: (2022)

Are High Levels of Microsatellite Instability and Microsatellite Stability Identical in DNA Mismatch Repair-Deficient Colorectal Cancer Patients?
por: Qiu, Yan-Yu, et al.
Publicado: (2023)

Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability
por: Chang, In-Youb, et al.
Publicado: (2005)

Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability
por: Chang, In-Youb, et al.
Publicado: (2005)

Pembrolizumab in Asian patients with microsatellite‐instability‐high/mismatch‐repair‐deficient colorectal cancer
por: Yoshino, Takayuki, et al.
Publicado: (2022)

Mitochondrial microsatellite instability in patients with metastatic colorectal cancer
por: Venderbosch, S., et al.
Publicado: (2015)

Analysis of Costs Associated With Administration of Intravenous Single-Drug Therapies in Metastatic Breast Cancer in a U.S. Population
por: Kruse, Gregory B., et al.
Publicado: (2008)

Concordance between microsatellite instability testing and immunohistochemistry for mismatch repair proteins and efficient screening of mismatch repair deficient gastric cancer
por: Yamamoto, Gou, et al.
Publicado: (2023)

Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability
por: Oda, Shinya, et al.
Publicado: (2005)

Editorial: Microsatellite and microsatellite instability
por: How-Kit, Alexandre, et al.
Publicado: (2023)

Discordance between immunochemistry of mismatch repair proteins and molecular testing of microsatellite instability in colorectal cancer
por: Guyot D'Asnières De Salins, A., et al.
Publicado: (2021)

The EMA assessment of pembrolizumab as monotherapy for the first-line treatment of adult patients with metastatic microsatellite instability-high or mismatch repair deficient colorectal cancer
por: Trullas, A., et al.
Publicado: (2021)

High-sensitivity microsatellite instability assessment for the detection of mismatch repair defects in normal tissue of biallelic germline mismatch repair mutation carriers
por: González-Acosta, Maribel, et al.
Publicado: (2020)

Microsatellite Instability and Metastatic Colorectal Cancer – A Clinical Perspective
por: Buchler, Tomas
Publicado: (2022)

Mismatch Repair Protein Loss as a Prognostic and Predictive Biomarker in Breast Cancers Regardless of Microsatellite Instability
por: Fusco, Nicola, et al.
Publicado: (2018)

DNA Mismatch Repair Deficiency Detection in Colorectal Cancer by a New Microsatellite Instability Analysis System
por: Wu, Shafei, et al.
Publicado: (2020)

Subcutaneous envafolimab monotherapy in patients with advanced defective mismatch repair/microsatellite instability high solid tumors
por: Li, Jian, et al.
Publicado: (2021)

Saffron and Its Major Ingredients’ Effect on Colon Cancer Cells with Mismatch Repair Deficiency and Microsatellite Instability
por: Amin, Amr, et al.
Publicado: (2021)

An Exceptional Response to Dostarlimab in Mismatch Repair Deficient, Microsatellite Instability-High and Platinum Refractory Endometrial Cancer
por: Bartoletti, Michele, et al.
Publicado: (2022)

Clinicopathological characteristics of high microsatellite instability/mismatch repair-deficient colorectal cancer: A narrative review
por: Mei, Wei-Jian, et al.
Publicado: (2022)

Efficacy and safety of preoperative immunotherapy in patients with mismatch repair-deficient or microsatellite instability-high gastrointestinal malignancies
por: Li, Ying-Jie, et al.
Publicado: (2023)

A Phase II Study of Avelumab Monotherapy in Patients with Mismatch Repair–Deficient/Microsatellite Instability–High or POLE-Mutated Metastatic or Unresectable Colorectal Cancer
por: Kim, Jwa Hoon, et al.
Publicado: (2020)

Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164
por: Le, Dung T., et al.
Publicado: (2020)

Efficacy of Immune Checkpoint Inhibitors in Patients with Mismatch Repair-Deficient or Microsatellite Instability-High Metastatic Colorectal Cancer: Analysis of Three Phase-II Trials
por: Cancanelli, Luca, et al.
Publicado: (2021)

Comparative Effectiveness of Immune Checkpoint Inhibitors vs Chemotherapy in Patients With Metastatic Colorectal Cancer With Measures of Microsatellite Instability, Mismatch Repair, or Tumor Mutational Burden
por: Quintanilha, Julia C. F., et al.
Publicado: (2023)

Retained Mismatch Repair Protein Expression Occurs in Approximately 6% of Microsatellite Instability-High Cancers and is Associated with Missense Mutations in Mismatch Repair Genes.
por: Hechtman, Jaclyn F., et al.
Publicado: (2019)

High Frequency of Microsatellite Instability among Non-Metastatic Gastric Cancer
por: Fanaei, Khadijeh, et al.
Publicado: (2022)

The cost-effectiveness analysis of serplulimab versus regorafenib for treating previously treated unresectable or metastatic microsatellite instability-high or deficient mismatch repair colorectal cancer in China
por: Ma, Yue, et al.
Publicado: (2023)

Utilizing microsatellite instability and immunohistochemistry to clinically interpret a novel germline mismatch repair mutation of uncertain significance
por: Ducaine, Whitney L, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_2ma6jhotcqeoukuifcj2gn4r1g