Cargando…

Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes

The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without...

Descripción completa

Detalles Bibliográficos
Autores principales: Castelblanco, Esmeralda, Betriu, Àngels, Hernández, Marta, Granado-Casas, Minerva, Ortega, Emilio, Soldevila, Berta, Ramírez-Morros, Anna, Franch-Nadal, Josep, Puig-Domingo, Manel, Fernández, Elvira, Avogaro, Angelo, Alonso, Núria, Mauricio, Dídac
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518191/
https://www.ncbi.nlm.nih.gov/pubmed/30925670
http://dx.doi.org/10.3390/jcm8040424
_version_ 1783418409763995648
author Castelblanco, Esmeralda
Betriu, Àngels
Hernández, Marta
Granado-Casas, Minerva
Ortega, Emilio
Soldevila, Berta
Ramírez-Morros, Anna
Franch-Nadal, Josep
Puig-Domingo, Manel
Fernández, Elvira
Avogaro, Angelo
Alonso, Núria
Mauricio, Dídac
author_facet Castelblanco, Esmeralda
Betriu, Àngels
Hernández, Marta
Granado-Casas, Minerva
Ortega, Emilio
Soldevila, Berta
Ramírez-Morros, Anna
Franch-Nadal, Josep
Puig-Domingo, Manel
Fernández, Elvira
Avogaro, Angelo
Alonso, Núria
Mauricio, Dídac
author_sort Castelblanco, Esmeralda
collection PubMed
description The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular disease. One hundred and seven patients with T1D (49.5% women; age 54 ± 9.8 years) and 67 control subjects without diabetes who had at least one carotid plaque were included in the study. The proportion of subjects who had only echolucent plaques was reduced in the group of patients with T1D (48.6% vs. 73.1%). In contrast, the proportion with only echogenic (25.2% vs. 7.5%) and calcified plaques (9.4% vs. 1.5%) was increased compared with subjects without diabetes. Moreover, having at least one echogenic plaque was more frequent in T1D patients compared with subjects without diabetes (49.5% vs. 26.9% p = 0.005). In addition to diabetes (OR 2.28; p = 0.026), age (OR 1.06, p = 0.002) was the other variable associated with echogenic plaque existence in multiple regression analysis. Patients with T1D exhibit a differential pattern of carotid plaque type compared with subjects without diabetes, with an increased frequency of echogenic and extensively calcified plaques.
format Online
Article
Text
id pubmed-6518191
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65181912019-05-31 Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes Castelblanco, Esmeralda Betriu, Àngels Hernández, Marta Granado-Casas, Minerva Ortega, Emilio Soldevila, Berta Ramírez-Morros, Anna Franch-Nadal, Josep Puig-Domingo, Manel Fernández, Elvira Avogaro, Angelo Alonso, Núria Mauricio, Dídac J Clin Med Article The aim of the study was to investigate ultrasound tissue characterization of carotid plaques in subjects with and without diabetes type 1 (T1D). B-mode carotid ultrasound was performed to assess the presence and type of plaque in a group of 340 subjects with and 304 without T1D, all of them without cardiovascular disease. One hundred and seven patients with T1D (49.5% women; age 54 ± 9.8 years) and 67 control subjects without diabetes who had at least one carotid plaque were included in the study. The proportion of subjects who had only echolucent plaques was reduced in the group of patients with T1D (48.6% vs. 73.1%). In contrast, the proportion with only echogenic (25.2% vs. 7.5%) and calcified plaques (9.4% vs. 1.5%) was increased compared with subjects without diabetes. Moreover, having at least one echogenic plaque was more frequent in T1D patients compared with subjects without diabetes (49.5% vs. 26.9% p = 0.005). In addition to diabetes (OR 2.28; p = 0.026), age (OR 1.06, p = 0.002) was the other variable associated with echogenic plaque existence in multiple regression analysis. Patients with T1D exhibit a differential pattern of carotid plaque type compared with subjects without diabetes, with an increased frequency of echogenic and extensively calcified plaques. MDPI 2019-03-28 /pmc/articles/PMC6518191/ /pubmed/30925670 http://dx.doi.org/10.3390/jcm8040424 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Castelblanco, Esmeralda
Betriu, Àngels
Hernández, Marta
Granado-Casas, Minerva
Ortega, Emilio
Soldevila, Berta
Ramírez-Morros, Anna
Franch-Nadal, Josep
Puig-Domingo, Manel
Fernández, Elvira
Avogaro, Angelo
Alonso, Núria
Mauricio, Dídac
Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_full Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_fullStr Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_full_unstemmed Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_short Ultrasound Tissue Characterization of Carotid Plaques Differs Between Patients with Type 1 Diabetes and Subjects without Diabetes
title_sort ultrasound tissue characterization of carotid plaques differs between patients with type 1 diabetes and subjects without diabetes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518191/
https://www.ncbi.nlm.nih.gov/pubmed/30925670
http://dx.doi.org/10.3390/jcm8040424
work_keys_str_mv AT castelblancoesmeralda ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT betriuangels ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT hernandezmarta ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT granadocasasminerva ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT ortegaemilio ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT soldevilaberta ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT ramirezmorrosanna ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT franchnadaljosep ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT puigdomingomanel ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT fernandezelvira ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT avogaroangelo ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT alonsonuria ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes
AT mauriciodidac ultrasoundtissuecharacterizationofcarotidplaquesdiffersbetweenpatientswithtype1diabetesandsubjectswithoutdiabetes