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HIV and cART-Associated Dyslipidemia Among HIV-Infected Children

Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian childre...

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Autores principales: Tadesse, Birkneh Tilahun, Foster, Byron Alexander, Chala, Adugna, Chaka, Tolossa Eticha, Bizuayehu, Temesgen, Ayalew, Freshwork, H/Meskel, Getahun, Tadesse, Sintayehu, Jerene, Degu, Makonnen, Eyasu, Aklillu, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518233/
https://www.ncbi.nlm.nih.gov/pubmed/30925831
http://dx.doi.org/10.3390/jcm8040430
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author Tadesse, Birkneh Tilahun
Foster, Byron Alexander
Chala, Adugna
Chaka, Tolossa Eticha
Bizuayehu, Temesgen
Ayalew, Freshwork
H/Meskel, Getahun
Tadesse, Sintayehu
Jerene, Degu
Makonnen, Eyasu
Aklillu, Eleni
author_facet Tadesse, Birkneh Tilahun
Foster, Byron Alexander
Chala, Adugna
Chaka, Tolossa Eticha
Bizuayehu, Temesgen
Ayalew, Freshwork
H/Meskel, Getahun
Tadesse, Sintayehu
Jerene, Degu
Makonnen, Eyasu
Aklillu, Eleni
author_sort Tadesse, Birkneh Tilahun
collection PubMed
description Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian children. Methods: 105 cART naïve and 215 treatment experienced HIV-infected children were enrolled from nine HIV centers. Demographic and clinical data, lipid profile, cART type, adherence to and duration on cART were recorded. Total, low density (LDLc) and high density (HDLc) cholesterol values >200 mg/dL, >130 mg/dL, <40 mg/dL, respectively; and/or, triglyceride values >150 mg/dL defined cases of dyslipidemia. Prevalence and predictors of dyslipidemia were compared between the two groups. Results: prevalence of dyslipidemia was significantly higher among cART experienced (70.2%) than treatment naïve (58.1%) children (p = 0.03). Prevalence of low HDLc (40.2% versus 23.4%, p = 0.006) and hypertriglyceridemia (47.2% versus 35.8%, p = 0.02) was higher among cART experienced than naïve children. There was no difference in total hypercholesterolemia and high LDLc levels. Nutrition state was associated with dyslipidemia among cART naïve children (p = 0.01). Conclusion: high prevalence of cART-associated dyslipidemia, particularly low HDLc and hypertriglyceridemia was observed among treatment experienced HIV-infected children. The findings underscore the need for regular follow up of children on cART for lipid abnormalities.
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spelling pubmed-65182332019-05-31 HIV and cART-Associated Dyslipidemia Among HIV-Infected Children Tadesse, Birkneh Tilahun Foster, Byron Alexander Chala, Adugna Chaka, Tolossa Eticha Bizuayehu, Temesgen Ayalew, Freshwork H/Meskel, Getahun Tadesse, Sintayehu Jerene, Degu Makonnen, Eyasu Aklillu, Eleni J Clin Med Article Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian children. Methods: 105 cART naïve and 215 treatment experienced HIV-infected children were enrolled from nine HIV centers. Demographic and clinical data, lipid profile, cART type, adherence to and duration on cART were recorded. Total, low density (LDLc) and high density (HDLc) cholesterol values >200 mg/dL, >130 mg/dL, <40 mg/dL, respectively; and/or, triglyceride values >150 mg/dL defined cases of dyslipidemia. Prevalence and predictors of dyslipidemia were compared between the two groups. Results: prevalence of dyslipidemia was significantly higher among cART experienced (70.2%) than treatment naïve (58.1%) children (p = 0.03). Prevalence of low HDLc (40.2% versus 23.4%, p = 0.006) and hypertriglyceridemia (47.2% versus 35.8%, p = 0.02) was higher among cART experienced than naïve children. There was no difference in total hypercholesterolemia and high LDLc levels. Nutrition state was associated with dyslipidemia among cART naïve children (p = 0.01). Conclusion: high prevalence of cART-associated dyslipidemia, particularly low HDLc and hypertriglyceridemia was observed among treatment experienced HIV-infected children. The findings underscore the need for regular follow up of children on cART for lipid abnormalities. MDPI 2019-03-28 /pmc/articles/PMC6518233/ /pubmed/30925831 http://dx.doi.org/10.3390/jcm8040430 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tadesse, Birkneh Tilahun
Foster, Byron Alexander
Chala, Adugna
Chaka, Tolossa Eticha
Bizuayehu, Temesgen
Ayalew, Freshwork
H/Meskel, Getahun
Tadesse, Sintayehu
Jerene, Degu
Makonnen, Eyasu
Aklillu, Eleni
HIV and cART-Associated Dyslipidemia Among HIV-Infected Children
title HIV and cART-Associated Dyslipidemia Among HIV-Infected Children
title_full HIV and cART-Associated Dyslipidemia Among HIV-Infected Children
title_fullStr HIV and cART-Associated Dyslipidemia Among HIV-Infected Children
title_full_unstemmed HIV and cART-Associated Dyslipidemia Among HIV-Infected Children
title_short HIV and cART-Associated Dyslipidemia Among HIV-Infected Children
title_sort hiv and cart-associated dyslipidemia among hiv-infected children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518233/
https://www.ncbi.nlm.nih.gov/pubmed/30925831
http://dx.doi.org/10.3390/jcm8040430
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