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HIV and cART-Associated Dyslipidemia Among HIV-Infected Children
Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian childre...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518233/ https://www.ncbi.nlm.nih.gov/pubmed/30925831 http://dx.doi.org/10.3390/jcm8040430 |
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author | Tadesse, Birkneh Tilahun Foster, Byron Alexander Chala, Adugna Chaka, Tolossa Eticha Bizuayehu, Temesgen Ayalew, Freshwork H/Meskel, Getahun Tadesse, Sintayehu Jerene, Degu Makonnen, Eyasu Aklillu, Eleni |
author_facet | Tadesse, Birkneh Tilahun Foster, Byron Alexander Chala, Adugna Chaka, Tolossa Eticha Bizuayehu, Temesgen Ayalew, Freshwork H/Meskel, Getahun Tadesse, Sintayehu Jerene, Degu Makonnen, Eyasu Aklillu, Eleni |
author_sort | Tadesse, Birkneh Tilahun |
collection | PubMed |
description | Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian children. Methods: 105 cART naïve and 215 treatment experienced HIV-infected children were enrolled from nine HIV centers. Demographic and clinical data, lipid profile, cART type, adherence to and duration on cART were recorded. Total, low density (LDLc) and high density (HDLc) cholesterol values >200 mg/dL, >130 mg/dL, <40 mg/dL, respectively; and/or, triglyceride values >150 mg/dL defined cases of dyslipidemia. Prevalence and predictors of dyslipidemia were compared between the two groups. Results: prevalence of dyslipidemia was significantly higher among cART experienced (70.2%) than treatment naïve (58.1%) children (p = 0.03). Prevalence of low HDLc (40.2% versus 23.4%, p = 0.006) and hypertriglyceridemia (47.2% versus 35.8%, p = 0.02) was higher among cART experienced than naïve children. There was no difference in total hypercholesterolemia and high LDLc levels. Nutrition state was associated with dyslipidemia among cART naïve children (p = 0.01). Conclusion: high prevalence of cART-associated dyslipidemia, particularly low HDLc and hypertriglyceridemia was observed among treatment experienced HIV-infected children. The findings underscore the need for regular follow up of children on cART for lipid abnormalities. |
format | Online Article Text |
id | pubmed-6518233 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65182332019-05-31 HIV and cART-Associated Dyslipidemia Among HIV-Infected Children Tadesse, Birkneh Tilahun Foster, Byron Alexander Chala, Adugna Chaka, Tolossa Eticha Bizuayehu, Temesgen Ayalew, Freshwork H/Meskel, Getahun Tadesse, Sintayehu Jerene, Degu Makonnen, Eyasu Aklillu, Eleni J Clin Med Article Background: Persistent dyslipidemia in children is associated with risks of cardiovascular accidents and poor combination antiretroviral therapy (cART) outcome. We report on the first evaluation of prevalence and associations with dyslipidemia due to HIV and cART among HIV-infected Ethiopian children. Methods: 105 cART naïve and 215 treatment experienced HIV-infected children were enrolled from nine HIV centers. Demographic and clinical data, lipid profile, cART type, adherence to and duration on cART were recorded. Total, low density (LDLc) and high density (HDLc) cholesterol values >200 mg/dL, >130 mg/dL, <40 mg/dL, respectively; and/or, triglyceride values >150 mg/dL defined cases of dyslipidemia. Prevalence and predictors of dyslipidemia were compared between the two groups. Results: prevalence of dyslipidemia was significantly higher among cART experienced (70.2%) than treatment naïve (58.1%) children (p = 0.03). Prevalence of low HDLc (40.2% versus 23.4%, p = 0.006) and hypertriglyceridemia (47.2% versus 35.8%, p = 0.02) was higher among cART experienced than naïve children. There was no difference in total hypercholesterolemia and high LDLc levels. Nutrition state was associated with dyslipidemia among cART naïve children (p = 0.01). Conclusion: high prevalence of cART-associated dyslipidemia, particularly low HDLc and hypertriglyceridemia was observed among treatment experienced HIV-infected children. The findings underscore the need for regular follow up of children on cART for lipid abnormalities. MDPI 2019-03-28 /pmc/articles/PMC6518233/ /pubmed/30925831 http://dx.doi.org/10.3390/jcm8040430 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tadesse, Birkneh Tilahun Foster, Byron Alexander Chala, Adugna Chaka, Tolossa Eticha Bizuayehu, Temesgen Ayalew, Freshwork H/Meskel, Getahun Tadesse, Sintayehu Jerene, Degu Makonnen, Eyasu Aklillu, Eleni HIV and cART-Associated Dyslipidemia Among HIV-Infected Children |
title | HIV and cART-Associated Dyslipidemia Among HIV-Infected Children |
title_full | HIV and cART-Associated Dyslipidemia Among HIV-Infected Children |
title_fullStr | HIV and cART-Associated Dyslipidemia Among HIV-Infected Children |
title_full_unstemmed | HIV and cART-Associated Dyslipidemia Among HIV-Infected Children |
title_short | HIV and cART-Associated Dyslipidemia Among HIV-Infected Children |
title_sort | hiv and cart-associated dyslipidemia among hiv-infected children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518233/ https://www.ncbi.nlm.nih.gov/pubmed/30925831 http://dx.doi.org/10.3390/jcm8040430 |
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