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Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study

To evaluate routine laboratory parameters in women with and without placental abruption (PA) and in controls, 417 women were included in this retrospective cohort study in a tertiary-care center. 118 women with PA (Group A: 54 without vaginal bleeding and Group B: 64 with bleeding), 130 women withou...

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Autores principales: Pils, Sophie, Paternostro, Chiara, Bekos, Christine, Hager, Marlene, Ristl, Robin, Ott, Johannes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518269/
https://www.ncbi.nlm.nih.gov/pubmed/30970668
http://dx.doi.org/10.3390/jcm8040482
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author Pils, Sophie
Paternostro, Chiara
Bekos, Christine
Hager, Marlene
Ristl, Robin
Ott, Johannes
author_facet Pils, Sophie
Paternostro, Chiara
Bekos, Christine
Hager, Marlene
Ristl, Robin
Ott, Johannes
author_sort Pils, Sophie
collection PubMed
description To evaluate routine laboratory parameters in women with and without placental abruption (PA) and in controls, 417 women were included in this retrospective cohort study in a tertiary-care center. 118 women with PA (Group A: 54 without vaginal bleeding and Group B: 64 with bleeding), 130 women without either PA or vaginal bleeding throughout their pregnancy (Group C), 123 women with vaginal bleeding but without PA (Group D), and 46 healthy pregnant women who had undergone a control laboratory evaluation in the second/third trimester for history of previous cytomegalovirus (additional control group) were included. Hemoglobin, leukocytes, thrombocytes, C-reactive protein (CRP), and fibrinogen were obtained within 48 h before C-section and/or at the time of bleeding onset. Cases (Groups A and B) revealed higher CRP levels than controls (Groups C and D) after multivariate analysis in the sub-analyses of bleeding (0.56 mg/dL, interquartile range (IQR) 0.28–1.24 vs. 0.51 mg/dL, IQR 0.28–0.84; odds ratio (OR) 1.108, p = 0.006) and non-bleeding women (0.64 mg/dL, IQR 0.48–1.08 vs. 0.32 mg/dL, IQR 0.18–0.61; OR 7.454, p < 0.001). The non-bleeding cases (Group A) revealed significantly higher leukocyte (12.01 g/L, IQR 9.41–14.10 vs. 9.21 g/L, IQR 7.95–10.49; OR 1.378, 95% confidence interval (CI): 1.095–1.735; p = 0.006) and CRP levels (0.64 mg/dL, IQR 0.48–1.08 vs. 0.33 mg/dL, IQR 0.20–0.50; OR 7.942, 95% CI: 1.435–43.958; p = 0.018) than the additional control group. In cases, none of the laboratory parameters differed between women with and without bleeding. The significantly increased CRP levels found for women with PA and the lack of a difference in CRP between bleeding and non-bleeding cases point toward a chronic process underlying placental abruption. However, this laboratory parameter does not seem clinically relevant for distinguishing between women with and without placental abruption at this point in time.
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spelling pubmed-65182692019-05-31 Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study Pils, Sophie Paternostro, Chiara Bekos, Christine Hager, Marlene Ristl, Robin Ott, Johannes J Clin Med Article To evaluate routine laboratory parameters in women with and without placental abruption (PA) and in controls, 417 women were included in this retrospective cohort study in a tertiary-care center. 118 women with PA (Group A: 54 without vaginal bleeding and Group B: 64 with bleeding), 130 women without either PA or vaginal bleeding throughout their pregnancy (Group C), 123 women with vaginal bleeding but without PA (Group D), and 46 healthy pregnant women who had undergone a control laboratory evaluation in the second/third trimester for history of previous cytomegalovirus (additional control group) were included. Hemoglobin, leukocytes, thrombocytes, C-reactive protein (CRP), and fibrinogen were obtained within 48 h before C-section and/or at the time of bleeding onset. Cases (Groups A and B) revealed higher CRP levels than controls (Groups C and D) after multivariate analysis in the sub-analyses of bleeding (0.56 mg/dL, interquartile range (IQR) 0.28–1.24 vs. 0.51 mg/dL, IQR 0.28–0.84; odds ratio (OR) 1.108, p = 0.006) and non-bleeding women (0.64 mg/dL, IQR 0.48–1.08 vs. 0.32 mg/dL, IQR 0.18–0.61; OR 7.454, p < 0.001). The non-bleeding cases (Group A) revealed significantly higher leukocyte (12.01 g/L, IQR 9.41–14.10 vs. 9.21 g/L, IQR 7.95–10.49; OR 1.378, 95% confidence interval (CI): 1.095–1.735; p = 0.006) and CRP levels (0.64 mg/dL, IQR 0.48–1.08 vs. 0.33 mg/dL, IQR 0.20–0.50; OR 7.942, 95% CI: 1.435–43.958; p = 0.018) than the additional control group. In cases, none of the laboratory parameters differed between women with and without bleeding. The significantly increased CRP levels found for women with PA and the lack of a difference in CRP between bleeding and non-bleeding cases point toward a chronic process underlying placental abruption. However, this laboratory parameter does not seem clinically relevant for distinguishing between women with and without placental abruption at this point in time. MDPI 2019-04-09 /pmc/articles/PMC6518269/ /pubmed/30970668 http://dx.doi.org/10.3390/jcm8040482 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pils, Sophie
Paternostro, Chiara
Bekos, Christine
Hager, Marlene
Ristl, Robin
Ott, Johannes
Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study
title Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study
title_full Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study
title_fullStr Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study
title_full_unstemmed Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study
title_short Prognostic Laboratory Parameters in Placental Abruption: A Retrospective Case-Control Study
title_sort prognostic laboratory parameters in placental abruption: a retrospective case-control study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518269/
https://www.ncbi.nlm.nih.gov/pubmed/30970668
http://dx.doi.org/10.3390/jcm8040482
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