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Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation
Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence sugges...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518405/ https://www.ncbi.nlm.nih.gov/pubmed/30978926 http://dx.doi.org/10.3390/jcm8040488 |
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author | Candow, Darren G. Forbes, Scott C. Chilibeck, Philip D. Cornish, Stephen M. Antonio, Jose Kreider, Richard B. |
author_facet | Candow, Darren G. Forbes, Scott C. Chilibeck, Philip D. Cornish, Stephen M. Antonio, Jose Kreider, Richard B. |
author_sort | Candow, Darren G. |
collection | PubMed |
description | Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults. |
format | Online Article Text |
id | pubmed-6518405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65184052019-05-31 Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation Candow, Darren G. Forbes, Scott C. Chilibeck, Philip D. Cornish, Stephen M. Antonio, Jose Kreider, Richard B. J Clin Med Review Sarcopenia, defined as the age-related decrease in muscle mass, strength and physical performance, is associated with reduced bone mass and elevated low-grade inflammation. From a healthy aging perspective, interventions which overcome sarcopenia are clinically relevant. Accumulating evidence suggests that exogenous creatine supplementation has the potential to increase aging muscle mass, muscle performance, and decrease the risk of falls and possibly attenuate inflammation and loss of bone mineral. Therefore, the purpose of this review is to: (1) summarize the effects of creatine supplementation, with and without resistance training, in aging adults and discuss possible mechanisms of action, (2) examine the effects of creatine on bone biology and risk of falls, (3) evaluate the potential anti-inflammatory effects of creatine and (4) determine the safety of creatine supplementation in aging adults. MDPI 2019-04-11 /pmc/articles/PMC6518405/ /pubmed/30978926 http://dx.doi.org/10.3390/jcm8040488 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Candow, Darren G. Forbes, Scott C. Chilibeck, Philip D. Cornish, Stephen M. Antonio, Jose Kreider, Richard B. Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation |
title | Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation |
title_full | Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation |
title_fullStr | Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation |
title_full_unstemmed | Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation |
title_short | Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation |
title_sort | effectiveness of creatine supplementation on aging muscle and bone: focus on falls prevention and inflammation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518405/ https://www.ncbi.nlm.nih.gov/pubmed/30978926 http://dx.doi.org/10.3390/jcm8040488 |
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