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Case Report: Gastric Mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of Helicobacter pylori endemicity

A 57 years female from the hills of Nepal presented with upper gastrointestinal bleeding with gastric ulcer evident on endoscopy. Though initially treated with Helicobacter pylori ( H. pylori) eradication therapy alone, biopsy later on revealed both mucormycosis and H. pylori infection. She was then...

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Autores principales: Adhikari, Sudeep, Gautam, Ajaya Raj, Paudyal, Buddhi, Sigdel, Keshav Raj, Basnyat, Buddha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518441/
https://www.ncbi.nlm.nih.gov/pubmed/31131332
http://dx.doi.org/10.12688/wellcomeopenres.15026.2
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author Adhikari, Sudeep
Gautam, Ajaya Raj
Paudyal, Buddhi
Sigdel, Keshav Raj
Basnyat, Buddha
author_facet Adhikari, Sudeep
Gautam, Ajaya Raj
Paudyal, Buddhi
Sigdel, Keshav Raj
Basnyat, Buddha
author_sort Adhikari, Sudeep
collection PubMed
description A 57 years female from the hills of Nepal presented with upper gastrointestinal bleeding with gastric ulcer evident on endoscopy. Though initially treated with Helicobacter pylori ( H. pylori) eradication therapy alone, biopsy later on revealed both mucormycosis and H. pylori infection. She was then treated with antifungals liposomal amphotericin B followed by posaconazole which led to complete recovery. Mucormycosis is a rare but life-threatening fungal disease of immunocompromised host though our patient was immunocompetent. If recognized and treated at early stage, as in our patient, prognosis is good. A high index of suspicion is required for considering this disease in H. pylori endemic regions such as Nepal, and is crucial for early recognition and treatment.
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spelling pubmed-65184412019-05-24 Case Report: Gastric Mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of Helicobacter pylori endemicity Adhikari, Sudeep Gautam, Ajaya Raj Paudyal, Buddhi Sigdel, Keshav Raj Basnyat, Buddha Wellcome Open Res Case Report A 57 years female from the hills of Nepal presented with upper gastrointestinal bleeding with gastric ulcer evident on endoscopy. Though initially treated with Helicobacter pylori ( H. pylori) eradication therapy alone, biopsy later on revealed both mucormycosis and H. pylori infection. She was then treated with antifungals liposomal amphotericin B followed by posaconazole which led to complete recovery. Mucormycosis is a rare but life-threatening fungal disease of immunocompromised host though our patient was immunocompetent. If recognized and treated at early stage, as in our patient, prognosis is good. A high index of suspicion is required for considering this disease in H. pylori endemic regions such as Nepal, and is crucial for early recognition and treatment. F1000 Research Limited 2019-03-27 /pmc/articles/PMC6518441/ /pubmed/31131332 http://dx.doi.org/10.12688/wellcomeopenres.15026.2 Text en Copyright: © 2019 Adhikari S et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Adhikari, Sudeep
Gautam, Ajaya Raj
Paudyal, Buddhi
Sigdel, Keshav Raj
Basnyat, Buddha
Case Report: Gastric Mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of Helicobacter pylori endemicity
title Case Report: Gastric Mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of Helicobacter pylori endemicity
title_full Case Report: Gastric Mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of Helicobacter pylori endemicity
title_fullStr Case Report: Gastric Mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of Helicobacter pylori endemicity
title_full_unstemmed Case Report: Gastric Mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of Helicobacter pylori endemicity
title_short Case Report: Gastric Mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of Helicobacter pylori endemicity
title_sort case report: gastric mucormycosis- a rare but important differential diagnosis of upper gastrointestinal bleeding in an area of helicobacter pylori endemicity
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518441/
https://www.ncbi.nlm.nih.gov/pubmed/31131332
http://dx.doi.org/10.12688/wellcomeopenres.15026.2
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