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Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study
BACKGROUND: The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Initiative for Chronic Obstructive Lung Disease (GOLD). Physical activity has emerg...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518503/ https://www.ncbi.nlm.nih.gov/pubmed/31088560 http://dx.doi.org/10.1186/s12931-019-1053-7 |
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author | Mihaltan, Florin Adir, Yochai Antczak, Adam Porpodis, Konstantinos Radulovic, Vesna Pires, Nuno de Vries, Geeuwke Jan Horner, Andreas De Bontridder, Samuel Chen, Yunqin Shavit, Anat Alecu, Silviu Adamek, Lukasz |
author_facet | Mihaltan, Florin Adir, Yochai Antczak, Adam Porpodis, Konstantinos Radulovic, Vesna Pires, Nuno de Vries, Geeuwke Jan Horner, Andreas De Bontridder, Samuel Chen, Yunqin Shavit, Anat Alecu, Silviu Adamek, Lukasz |
author_sort | Mihaltan, Florin |
collection | PubMed |
description | BACKGROUND: The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Initiative for Chronic Obstructive Lung Disease (GOLD). Physical activity has emerged as both functional outcome and non-pharmacological intervention in COPD patients, despite the lack of standardized measures or guidelines in clinical practice. This study aimed to explore in more depth the 24-h respiratory symptoms, the physical activity level (PAL) and the relationship between these two determinants in stable COPD patients. METHODS: This was a multinational, multicenter, observational, cross-sectional study conducted in ten European countries and Israel. Dedicated questionnaires for each part of the day (morning, daytime, night) were used to assess respiratory symptoms. PAL was evaluated with self- and interview-reported tools [EVS (exercise as vital sign) and YPAS (Yale Physical Activity Survey)], and physician’s judgement. Patients were stratified in ABCD groups by 2013 and 2017 GOLD editions using the questionnaires currently recommended: modified Medical Research Council dyspnea scale and COPD Assessment Test. RESULTS: The study enrolled 2190 patients (mean age: 66.9 years; male: 70.0%; mean % predicted FEV1: 52.6; GOLD groups II-III: 84.5%; any COPD treatment: 98.9%). Most patients (> 90%) reported symptoms in any part of the 24-h day, irrespective of COPD severity. PAL evaluations showed discordant results between patients and physicians: 32.9% of patients considered themselves completely inactive, while physicians judged 11.9% patients as inactive. By YPAS, the overall study population spent an average of 21.0 h/week performing physical activity, and 68.4% of patients were identified as sedentary. In any GOLD ABCD group, the percentage of inactive patients was high. Our study found negative, weak correlations between respiratory symptoms and self-reported PAL (p < 0.001). CONCLUSIONS: Despite regular treatment, the majority of stable COPD patients with moderate to severe disease experienced daily variable symptoms. Physical activity level was low in this COPD cohort, and yet overestimated by physicians. With evidence indicating the negative consequences of inactivity, its adequate screening, a more active promotion and regular assessment of physical activity are urgently needed in COPD patients for better outcomes. TRIAL REGISTRATION: NCT03031769, retrospectively registered, 23 Jan 2017. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12931-019-1053-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6518503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-65185032019-05-21 Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study Mihaltan, Florin Adir, Yochai Antczak, Adam Porpodis, Konstantinos Radulovic, Vesna Pires, Nuno de Vries, Geeuwke Jan Horner, Andreas De Bontridder, Samuel Chen, Yunqin Shavit, Anat Alecu, Silviu Adamek, Lukasz Respir Res Research BACKGROUND: The burden of symptoms and risk of exacerbations are the main drivers of the overall assessment of the Chronic Obstructive Pulmonary Disease (COPD) and the adequate treatment approaches per current Global Initiative for Chronic Obstructive Lung Disease (GOLD). Physical activity has emerged as both functional outcome and non-pharmacological intervention in COPD patients, despite the lack of standardized measures or guidelines in clinical practice. This study aimed to explore in more depth the 24-h respiratory symptoms, the physical activity level (PAL) and the relationship between these two determinants in stable COPD patients. METHODS: This was a multinational, multicenter, observational, cross-sectional study conducted in ten European countries and Israel. Dedicated questionnaires for each part of the day (morning, daytime, night) were used to assess respiratory symptoms. PAL was evaluated with self- and interview-reported tools [EVS (exercise as vital sign) and YPAS (Yale Physical Activity Survey)], and physician’s judgement. Patients were stratified in ABCD groups by 2013 and 2017 GOLD editions using the questionnaires currently recommended: modified Medical Research Council dyspnea scale and COPD Assessment Test. RESULTS: The study enrolled 2190 patients (mean age: 66.9 years; male: 70.0%; mean % predicted FEV1: 52.6; GOLD groups II-III: 84.5%; any COPD treatment: 98.9%). Most patients (> 90%) reported symptoms in any part of the 24-h day, irrespective of COPD severity. PAL evaluations showed discordant results between patients and physicians: 32.9% of patients considered themselves completely inactive, while physicians judged 11.9% patients as inactive. By YPAS, the overall study population spent an average of 21.0 h/week performing physical activity, and 68.4% of patients were identified as sedentary. In any GOLD ABCD group, the percentage of inactive patients was high. Our study found negative, weak correlations between respiratory symptoms and self-reported PAL (p < 0.001). CONCLUSIONS: Despite regular treatment, the majority of stable COPD patients with moderate to severe disease experienced daily variable symptoms. Physical activity level was low in this COPD cohort, and yet overestimated by physicians. With evidence indicating the negative consequences of inactivity, its adequate screening, a more active promotion and regular assessment of physical activity are urgently needed in COPD patients for better outcomes. TRIAL REGISTRATION: NCT03031769, retrospectively registered, 23 Jan 2017. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12931-019-1053-7) contains supplementary material, which is available to authorized users. BioMed Central 2019-05-14 2019 /pmc/articles/PMC6518503/ /pubmed/31088560 http://dx.doi.org/10.1186/s12931-019-1053-7 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Mihaltan, Florin Adir, Yochai Antczak, Adam Porpodis, Konstantinos Radulovic, Vesna Pires, Nuno de Vries, Geeuwke Jan Horner, Andreas De Bontridder, Samuel Chen, Yunqin Shavit, Anat Alecu, Silviu Adamek, Lukasz Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study |
title | Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study |
title_full | Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study |
title_fullStr | Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study |
title_full_unstemmed | Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study |
title_short | Importance of the relationship between symptoms and self-reported physical activity level in stable COPD based on the results from the SPACE study |
title_sort | importance of the relationship between symptoms and self-reported physical activity level in stable copd based on the results from the space study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518503/ https://www.ncbi.nlm.nih.gov/pubmed/31088560 http://dx.doi.org/10.1186/s12931-019-1053-7 |
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