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Prognostic implications and interaction of L1 methylation and p53 expression statuses in advanced gastric cancer

BACKGROUND: TP53 is frequently mutated across various tissue types of cancers. In normal cells, long interspersed nuclear element-1 (LINE-1, L1) is mostly repressed by DNA methylation in its 5′ untranslated region but is activated by DNA demethylation process during tumorigenesis. p53 is indispensab...

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Detalles Bibliográficos
Autores principales:	Shin, Yun-Joo, Kim, Younghoon, Wen, Xianyu, Cho, Nam-Yun, Lee, Sun, Kim, Woo Ho, Kang, Gyeong Hoon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518708/ https://www.ncbi.nlm.nih.gov/pubmed/31088544 http://dx.doi.org/10.1186/s13148-019-0661-x

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