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Gluconate suppresses seizure activity in developing brains by inhibiting CLC-3 chloride channels

Neonatal seizures are different from adult seizures, and many antiepileptic drugs that are effective in adults often fail to treat neonates. Here, we report that gluconate inhibits neonatal seizure by inhibiting CLC-3 chloride channels. We detect a voltage-dependent outward rectifying Cl(−) current...

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Detalles Bibliográficos
Autores principales:	Wu, Zheng, Huo, Qingwei, Ren, Liang, Dong, Fengping, Feng, Mengyang, Wang, Yue, Bai, Yuting, Lüscher, Bernhard, Li, Sheng-Tian, Wang, Guan-Lei, Long, Cheng, Wang, Yun, Wu, Gangyi, Chen, Gong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518791/ https://www.ncbi.nlm.nih.gov/pubmed/31088565 http://dx.doi.org/10.1186/s13041-019-0465-0

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