C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6

BACKGROUND: In its RING domain, tumor necrosis factor receptor-associated factor 6 (TRAF6) has ubiquitin E3 ligase activity that facilitates the formation of lysine 63-linked polyubiquitin chains. This activity is required to activate nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB...

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Detalles Bibliográficos
Autores principales: Jang, Hyun-Duk, Hwang, Hye Zin, Kim, Hyo-Soo, Lee, Soo Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518801/
https://www.ncbi.nlm.nih.gov/pubmed/31123462
http://dx.doi.org/10.1186/s11658-019-0156-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518801/
https://www.ncbi.nlm.nih.gov/pubmed/31123462
http://dx.doi.org/10.1186/s11658-019-0156-y

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