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C-Cbl negatively regulates TRAF6-mediated NF-κB activation by promoting K48-linked polyubiquitination of TRAF6

BACKGROUND: In its RING domain, tumor necrosis factor receptor-associated factor 6 (TRAF6) has ubiquitin E3 ligase activity that facilitates the formation of lysine 63-linked polyubiquitin chains. This activity is required to activate nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB...

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Detalles Bibliográficos
Autores principales:	Jang, Hyun-Duk, Hwang, Hye Zin, Kim, Hyo-Soo, Lee, Soo Young
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2019
Materias:	Research Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518801/ https://www.ncbi.nlm.nih.gov/pubmed/31123462 http://dx.doi.org/10.1186/s11658-019-0156-y

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