The thymidine dideoxynucleoside analog, alovudine, inhibits the mitochondrial DNA polymerase γ, impairs oxidative phosphorylation and promotes monocytic differentiation in acute myeloid leukemia

Mitochondrial DNA encodes 13 proteins that comprise components of the respiratory chain that maintain oxidative phosphorylation. The replication of mitochondrial DNA is performed by the sole mitochondrial DNA polymerase γ. As acute myeloid leukemia (AML) cells and stem cells have an increased relian...

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Detalles Bibliográficos
Autores principales: Yehudai, Dana, Liyanage, Sanduni U., Hurren, Rose, Rizoska, Biljana, Albertella, Mark, Gronda, Marcela, Jeyaraju, Danny V, Wang, Xiaoming, Barghout, Samir H., MacLean, Neil, Siriwardena, Thirushi P., Jitkova, Yulia, Targett-Adams, Paul, Schimmer, Aaron D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ferrata Storti Foundation 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518883/
https://www.ncbi.nlm.nih.gov/pubmed/30573504
http://dx.doi.org/10.3324/haematol.2018.195172

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