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Targeting intermediary metabolism enhances the efficacy of BH3 mimetic therapy in hematologic malignancies
BH3 mimetics are novel targeted drugs with remarkable specificity, potency and enormous potential to improve cancer therapy. However, acquired resistance is an emerging problem. We report the rapid development of resistance in chronic lymphocytic leukemia cells isolated from patients exposed to incr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ferrata Storti Foundation
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518917/ https://www.ncbi.nlm.nih.gov/pubmed/30467206 http://dx.doi.org/10.3324/haematol.2018.204701 |