Cargando…

Dual‐specificity phosphatase 6 deletion protects the colonic epithelium against inflammation and promotes both proliferation and tumorigenesis

The Ras/mitogen‐activated protein kinase (MAPK) pathway controls fundamental cellular processes such as proliferation, differentiation, and apoptosis. The dual‐specificity phosphatase 6 (DUSP6) regulates cytoplasmic MAPK signaling by dephosphorylating and inactivating extracellular signal‐regulated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Beaudry, Katia, Langlois, Marie‐Josée, Montagne, Amélie, Cagnol, Sébastien, Carrier, Julie C., Rivard, Nathalie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519001/ https://www.ncbi.nlm.nih.gov/pubmed/30273442 http://dx.doi.org/10.1002/jcp.27420

Ejemplares similares

Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis
por: Bian, Benjamin, et al.
Publicado: (2015)

The serine protease inhibitor serpinE2 is a novel target of ERK signaling involved in human colorectal tumorigenesis
por: Bergeron, Sébastien, et al.
Publicado: (2010)

Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer
por: Lemieux, E, et al.
Publicado: (2015)

The PTEN Phosphatase Controls Intestinal Epithelial Cell Polarity and Barrier Function: Role in Colorectal Cancer Progression
por: Langlois, Marie-Josée, et al.
Publicado: (2010)

ERK-associated changes in E2F4 phosphorylation, localization and transcriptional activity during mitogenic stimulation in human intestinal epithelial crypt cells
por: Paquin, Marie-Christine, et al.
Publicado: (2013)

SHP-2 phosphatase contributes to KRAS-driven intestinal oncogenesis but prevents colitis-associated cancer development
por: Gagné-Sansfaçon, Jessica, et al.
Publicado: (2016)

The tyrosine phosphatase Shp‐2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration
por: Gagné‐Sansfacon, Jessica, et al.
Publicado: (2018)

SHP‐2 Phosphatase Prevents Colonic Inflammation by Controlling Secretory Cell Differentiation and Maintaining Host‐Microbiota Homeostasis
por: Coulombe, Geneviève, et al.
Publicado: (2016)

Loss of PTEN Signaling in Foxl1(+) Mesenchymal Telocytes Initiates Spontaneous Colonic Neoplasia in Mice
por: Langlois, Marie-Josée, et al.
Publicado: (2019)

Tumorigenesis and peritoneal colonization from fallopian tube epithelium
por: Eddie, Sharon L., et al.
Publicado: (2015)

Contribution of ATOH1(+) Cells to the Homeostasis, Repair, and Tumorigenesis of the Colonic Epithelium
por: Ishibashi, Fumiaki, et al.
Publicado: (2017)

Interaction of the Hippo Pathway and Phosphatases in Tumorigenesis
por: Sarmasti Emami, Sahar, et al.
Publicado: (2020)

The MEK2-binding tumor suppressor hDlg is recruited by E-cadherin to the midbody ring
por: Gaudet, Suzanne, et al.
Publicado: (2011)

Unveiling the Roles of Low-Density Lipoprotein Receptor-Related Protein 6 in Intestinal Homeostasis, Regeneration and Oncogenesis
por: Raisch, Jennifer, et al.
Publicado: (2021)

Deletion of Dual Specificity Phosphatase 1 Does Not Predispose Mice to Increased Spontaneous Osteoarthritis
por: Pest, Michael Andrew, et al.
Publicado: (2015)

G-quadruplex located in the 5′UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance
por: Jodoin, Rachel, et al.
Publicado: (2019)

Phosphatases in toll-like receptors signaling: the unfairly-forgotten
por: Lannoy, Valérie, et al.
Publicado: (2021)

Phosphatase, pseudo-phosphatase, or both? Understanding PRL oncogenicity
por: Gehring, Kalle, et al.
Publicado: (2020)

Loss of Hepatocyte-Nuclear-Factor-1α Impacts on Adult Mouse Intestinal Epithelial Cell Growth and Cell Lineages Differentiation
por: Lussier, Carine R., et al.
Publicado: (2010)

New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal Tract
por: Coulombe, Geneviève, et al.
Publicado: (2015)

Dual-specificity phosphatase 3 deletion promotes obesity, non-alcoholic steatohepatitis and hepatocellular carcinoma
por: Jacques, Sophie, et al.
Publicado: (2021)

STIM1 Deficiency In Intestinal Epithelium Attenuates Colonic Inflammation and Tumorigenesis by Reducing ER Stress of Goblet Cells
por: Liang, Xiaojing, et al.
Publicado: (2022)

Loss of T-cell protein tyrosine phosphatase in the intestinal epithelium promotes local inflammation by increasing colonic stem cell proliferation
por: Bussières-Marmen, Stéphanie, et al.
Publicado: (2017)

Targeted deletion of keratin 8 in intestinal epithelial cells disrupts tissue integrity and predisposes to tumorigenesis in the colon
por: Stenvall, Carl-Gustaf A., et al.
Publicado: (2021)

Phosphatase and tensin homologue deleted on chromosome 10
por: Abdulkareem, Imran Haruna, et al.
Publicado: (2013)

Intestinal microbiota profiles in a genetic model of colon tumorigenesis correlates with colon cancer biomarkers
por: Vitali, Francesco, et al.
Publicado: (2022)

AMP‐activated protein kinase β1 or β2 deletion enhances colon cancer cell growth and tumorigenesis: Effects of AMPKβ1 or β2 deletion in colon cancer
por: Shi, Fuli, et al.
Publicado: (2022)

Role of the Protein Tyrosine Phosphatase Shp2 in Homeostasis of the Intestinal Epithelium
por: Yamashita, Hironori, et al.
Publicado: (2014)

Tissue-Specific Effects of Reduced β-catenin Expression on Adenomatous Polyposis Coli Mutation-Instigated Tumorigenesis in Mouse Colon and Ovarian Epithelium
por: Feng, Ying, et al.
Publicado: (2015)

Targeted Deletion of the Metastasis-Associated Phosphatase Ptp4a3 (PRL-3) Suppresses Murine Colon Cancer
por: Zimmerman, Mark W., et al.
Publicado: (2013)

Overexpression of SHP2 tyrosine phosphatase promotes the tumorigenesis of breast carcinoma
por: Hu, Zhongqian, et al.
Publicado: (2017)

Dual Function of Par3 in Tumorigenesis
por: Lv, Tao, et al.
Publicado: (2022)

The Gut Microbiome Modulates Colon Tumorigenesis
por: Zackular, Joseph P., et al.
Publicado: (2013)

Intestinal Iron Homeostasis and Colon Tumorigenesis
por: Xue, Xiang, et al.
Publicado: (2013)

LOCALIZATION OF ESTERASE AND ACID PHOSPHATASE IN GRANULES AND COLLOID DROPLETS IN RAT THYROID EPITHELIUM
por: Wollman, Seymour H., et al.
Publicado: (1964)

Deletion of Ptprd and Cdkn2a cooperate to accelerate tumorigenesis
por: Ortiz, Berenice, et al.
Publicado: (2014)

The Dual Function of KDM5C in Both Gene Transcriptional Activation and Repression Promotes Breast Cancer Cell Growth and Tumorigenesis
por: Shen, Hai‐feng, et al.
Publicado: (2021)

Knockdown of Forkhead box A1 suppresses the tumorigenesis and progression of human colon cancer cells through regulating the phosphatase and tensin homolog/Akt pathway
por: Pan, Jie, et al.
Publicado: (2020)

Dual-Specificity Phosphatases in Immunity and Infection: An Update
por: Lang, Roland, et al.
Publicado: (2019)

LIN28B promotes growth and tumorigenesis of the intestinal epithelium via Let-7
por: Madison, Blair B., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tk76432mspf5gc5fet2b1jk1mn