Cargando…

Demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular Degree II furcation defects: A clinical and cone beam computed tomography study

BACKGROUND: Currently, there is no gold-standard regenerative material for the treatment of furcation defects. The use of bone grafts in combination with guided tissue regeneration membrane is a predictable treatment option but is expensive. Platelet concentrates are increasingly being used owing to...

Descripción completa

Detalles Bibliográficos
Autores principales: Basireddy, Aravinda, Prathypaty, Santha Kumari, Yendluri, Durga Bai, Potharaju, Santi Priya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519103/
https://www.ncbi.nlm.nih.gov/pubmed/31143005
http://dx.doi.org/10.4103/jisp.jisp_465_18
_version_ 1783418580925153280
author Basireddy, Aravinda
Prathypaty, Santha Kumari
Yendluri, Durga Bai
Potharaju, Santi Priya
author_facet Basireddy, Aravinda
Prathypaty, Santha Kumari
Yendluri, Durga Bai
Potharaju, Santi Priya
author_sort Basireddy, Aravinda
collection PubMed
description BACKGROUND: Currently, there is no gold-standard regenerative material for the treatment of furcation defects. The use of bone grafts in combination with guided tissue regeneration membrane is a predictable treatment option but is expensive. Platelet concentrates are increasingly being used owing to their ease of use and cost-effectiveness. AIMS: The aim of this study is to evaluate the ability of platelet-rich fibrin (PRF) to augment the regenerative effects exerted by demineralized freeze-dried bone allograft (DFDBA) in the treatment of mandibular degree II furcation defects. MATERIALS AND METHODS: Twenty-eight defects in 14 patients with bilateral Degree II mandibular furcation defects were included in the study. The test group was treated with a combination of DFDBA and PRF, while in the control group DFDBA was used alone. Clinical parameters such as probing depth, relative vertical clinical attachment level, relative horizontal clinical attachment level (RHCAL), gingival margin level (GML), plaque index, and sulcus bleeding index were measured at baseline and 6 months. Radiographic parameters, such as vertical defect depth, horizontal defect depth and defect fill, were measured using cone beam computed tomography, taken at baseline and 6 months. STATISTICAL ANALYSIS USED: The intragroup and intergroup comparisons were done using the paired t-test. RESULTS: The intergroup comparison of mean change in the parameters showed, statistically significant difference in RHCAL (<0.001) and GML (0.014), and no significant difference in other parameters. CONCLUSIONS: Within the limitations of the present study, PRF seems to favor soft-tissue healing but has no additional benefit in bone regeneration when used in combination with DFDBA.
format Online
Article
Text
id pubmed-6519103
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-65191032019-05-29 Demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular Degree II furcation defects: A clinical and cone beam computed tomography study Basireddy, Aravinda Prathypaty, Santha Kumari Yendluri, Durga Bai Potharaju, Santi Priya J Indian Soc Periodontol Original Article BACKGROUND: Currently, there is no gold-standard regenerative material for the treatment of furcation defects. The use of bone grafts in combination with guided tissue regeneration membrane is a predictable treatment option but is expensive. Platelet concentrates are increasingly being used owing to their ease of use and cost-effectiveness. AIMS: The aim of this study is to evaluate the ability of platelet-rich fibrin (PRF) to augment the regenerative effects exerted by demineralized freeze-dried bone allograft (DFDBA) in the treatment of mandibular degree II furcation defects. MATERIALS AND METHODS: Twenty-eight defects in 14 patients with bilateral Degree II mandibular furcation defects were included in the study. The test group was treated with a combination of DFDBA and PRF, while in the control group DFDBA was used alone. Clinical parameters such as probing depth, relative vertical clinical attachment level, relative horizontal clinical attachment level (RHCAL), gingival margin level (GML), plaque index, and sulcus bleeding index were measured at baseline and 6 months. Radiographic parameters, such as vertical defect depth, horizontal defect depth and defect fill, were measured using cone beam computed tomography, taken at baseline and 6 months. STATISTICAL ANALYSIS USED: The intragroup and intergroup comparisons were done using the paired t-test. RESULTS: The intergroup comparison of mean change in the parameters showed, statistically significant difference in RHCAL (<0.001) and GML (0.014), and no significant difference in other parameters. CONCLUSIONS: Within the limitations of the present study, PRF seems to favor soft-tissue healing but has no additional benefit in bone regeneration when used in combination with DFDBA. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6519103/ /pubmed/31143005 http://dx.doi.org/10.4103/jisp.jisp_465_18 Text en Copyright: © 2019 Journal of Indian Society of Periodontology http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Basireddy, Aravinda
Prathypaty, Santha Kumari
Yendluri, Durga Bai
Potharaju, Santi Priya
Demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular Degree II furcation defects: A clinical and cone beam computed tomography study
title Demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular Degree II furcation defects: A clinical and cone beam computed tomography study
title_full Demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular Degree II furcation defects: A clinical and cone beam computed tomography study
title_fullStr Demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular Degree II furcation defects: A clinical and cone beam computed tomography study
title_full_unstemmed Demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular Degree II furcation defects: A clinical and cone beam computed tomography study
title_short Demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular Degree II furcation defects: A clinical and cone beam computed tomography study
title_sort demineralized freeze-dried bone allograft with or without platelet-rich fibrin in the treatment of mandibular degree ii furcation defects: a clinical and cone beam computed tomography study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519103/
https://www.ncbi.nlm.nih.gov/pubmed/31143005
http://dx.doi.org/10.4103/jisp.jisp_465_18
work_keys_str_mv AT basireddyaravinda demineralizedfreezedriedboneallograftwithorwithoutplateletrichfibrininthetreatmentofmandibulardegreeiifurcationdefectsaclinicalandconebeamcomputedtomographystudy
AT prathypatysanthakumari demineralizedfreezedriedboneallograftwithorwithoutplateletrichfibrininthetreatmentofmandibulardegreeiifurcationdefectsaclinicalandconebeamcomputedtomographystudy
AT yendluridurgabai demineralizedfreezedriedboneallograftwithorwithoutplateletrichfibrininthetreatmentofmandibulardegreeiifurcationdefectsaclinicalandconebeamcomputedtomographystudy
AT potharajusantipriya demineralizedfreezedriedboneallograftwithorwithoutplateletrichfibrininthetreatmentofmandibulardegreeiifurcationdefectsaclinicalandconebeamcomputedtomographystudy