Directed Evolution of a Designer Enzyme Featuring an Unnatural Catalytic Amino Acid

The impressive rate accelerations that enzymes display in nature often result from boosting the inherent catalytic activities of side chains by their precise positioning inside a protein binding pocket. Such fine‐tuning is also possible for catalytic unnatural amino acids. Specifically, the directed...

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Detalles Bibliográficos
Autores principales: Mayer, Clemens, Dulson, Christopher, Reddem, Eswar, Thunnissen, Andy‐Mark W. H., Roelfes, Gerard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519144/
https://www.ncbi.nlm.nih.gov/pubmed/30575260
http://dx.doi.org/10.1002/anie.201813499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519144/
https://www.ncbi.nlm.nih.gov/pubmed/30575260
http://dx.doi.org/10.1002/anie.201813499

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