N‐acetylcysteine targets 5 lipoxygenase‐derived, toxic lipids and can synergize with prostaglandin E(2) to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

OBJECTIVES: N‐acetylcysteine (NAC) is a clinically approved thiol‐containing redox modulatory compound currently in trials for many neurological and psychiatric disorders. Although generically labeled as an “antioxidant,” poor understanding of its site(s) of action is a barrier to its use in neurolo...

Descripción completa

Detalles Bibliográficos
Autores principales: Karuppagounder, Saravanan S., Alin, Lauren, Chen, Yingxin, Brand, David, Bourassa, Megan W., Dietrich, Kristen, Wilkinson, Cassandra M., Nadeau, Colby A., Kumar, Amit, Perry, Steve, Pinto, John T., Darley‐Usmar, Victor, Sanchez, Stephanie, Milne, Ginger L., Pratico, Domenico, Holman, Theodore R., Carmichael, S. Thomas, Coppola, Giovanni, Colbourne, Frederick, Ratan, Rajiv R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519209/
https://www.ncbi.nlm.nih.gov/pubmed/30294906
http://dx.doi.org/10.1002/ana.25356

Ejemplares similares

Ejemplares similares