Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force

This review describes the history, development, and evolution of cell‐based replacement therapy for Parkinson's disease (PD), from the first pioneering trials with fetal ventral midbrain progenitors to future trials using stem cells as well as reprogrammed cells. In the spirit of Tom Isaacs, th...

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Detalles Bibliográficos
Autores principales: Parmar, Malin, Torper, Olof, Drouin‐Ouellet, Janelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Tom Isaacs Special Issue
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519227/
https://www.ncbi.nlm.nih.gov/pubmed/30099795
http://dx.doi.org/10.1111/ejn.14109
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author Parmar, Malin
Torper, Olof
Drouin‐Ouellet, Janelle
author_facet Parmar, Malin
Torper, Olof
Drouin‐Ouellet, Janelle
author_sort Parmar, Malin
collection PubMed
description This review describes the history, development, and evolution of cell‐based replacement therapy for Parkinson's disease (PD), from the first pioneering trials with fetal ventral midbrain progenitors to future trials using stem cells as well as reprogrammed cells. In the spirit of Tom Isaacs, the review takes parallels to the storyline of Star Wars, including the temptations from the dark side and the continuous fight for the light side of the Force. It is subdivided into headings based on the original movies, spanning from A New Hope to the Last Jedi.
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spelling pubmed-65192272019-05-21 Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force Parmar, Malin Torper, Olof Drouin‐Ouellet, Janelle Eur J Neurosci Tom Isaacs Special Issue This review describes the history, development, and evolution of cell‐based replacement therapy for Parkinson's disease (PD), from the first pioneering trials with fetal ventral midbrain progenitors to future trials using stem cells as well as reprogrammed cells. In the spirit of Tom Isaacs, the review takes parallels to the storyline of Star Wars, including the temptations from the dark side and the continuous fight for the light side of the Force. It is subdivided into headings based on the original movies, spanning from A New Hope to the Last Jedi. John Wiley and Sons Inc. 2018-09-09 2019-02 /pmc/articles/PMC6519227/ /pubmed/30099795 http://dx.doi.org/10.1111/ejn.14109 Text en © 2018 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Tom Isaacs Special Issue
Parmar, Malin
Torper, Olof
Drouin‐Ouellet, Janelle
Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force
title Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force
title_full Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force
title_fullStr Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force
title_full_unstemmed Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force
title_short Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force
title_sort cell‐based therapy for parkinson's disease: a journey through decades toward the light side of the force
topic Tom Isaacs Special Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519227/
https://www.ncbi.nlm.nih.gov/pubmed/30099795
http://dx.doi.org/10.1111/ejn.14109
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