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Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion

BACKGROUND: One of the primary biomechanical factors influencing arterial health is their deformation across the cardiac cycle, or cyclic strain, which is often associated with arterial stiffness. Deleterious changes in the cardiovascular system, e.g., increased arterial stiffness, can remain undete...

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Autores principales: Castle, Paige E., Scheven, Ulrich M., Crouch, A. Colleen, Cao, Amos A., Goergen, Craig J., Greve, Joan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519256/
https://www.ncbi.nlm.nih.gov/pubmed/30291650
http://dx.doi.org/10.1002/jmri.26232
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author Castle, Paige E.
Scheven, Ulrich M.
Crouch, A. Colleen
Cao, Amos A.
Goergen, Craig J.
Greve, Joan M.
author_facet Castle, Paige E.
Scheven, Ulrich M.
Crouch, A. Colleen
Cao, Amos A.
Goergen, Craig J.
Greve, Joan M.
author_sort Castle, Paige E.
collection PubMed
description BACKGROUND: One of the primary biomechanical factors influencing arterial health is their deformation across the cardiac cycle, or cyclic strain, which is often associated with arterial stiffness. Deleterious changes in the cardiovascular system, e.g., increased arterial stiffness, can remain undetected until the system is challenged, such as under a cardiac stressor like dobutamine. PURPOSE: To quantify cyclic strain in mice at different locations along the arterial tree prior to and during dobutamine infusion, while evaluating the effects of sex and age. STUDY TYPE: Control/cohort study. ANIMAL MODEL: Twenty C57BL/6 mice; male, female; ∼12 and 24 weeks of age; n = 5 per group. FIELD STRENGTH/SEQUENCE: 7T; CINE MRI with 12 frames, velocity compensation, and prospective cardiac gating. ASSESSMENT: Prior to and during the infusion of dobutamine, Green–Lagrange circumferential cyclic strain was calculated from perimeter measurements derived from CINE data acquired at the carotid artery, suprarenal and infrarenal abdominal aorta, and iliac artery. STATISTICAL TESTS: Analysis of variance (ANOVA) followed by post‐hoc tests was used to evaluate the influence of dobutamine, anatomical location, sex, and age. RESULTS: Heart rates did not differ between groups prior to or during dobutamine infusion (P = 0.87 and P = 0.08, respectively). Dobutamine increased cyclic strain in each group. Within a group, increases in strain were similar across arteries. At the suprarenal aorta, strain was reduced in older mice at baseline (young 27.6 > mature 19.3%, P = 0.01) and during dobutamine infusion (young 53.0 > mature 36.2%, P = 0.005). In the infrarenal aorta, the response (dobutamine – baseline) was reduced in older mice (young 21.9 > mature 13.5%, P = 0.04). DATA CONCLUSION: Dobutamine infusion increases circumferential cyclic strain throughout the arterial tree of mice. This effect is quantifiable using CINE MRI. The results demonstrate that strain prior to and during dobutamine is influenced by anatomical location, sex, and age. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:69–80.
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spelling pubmed-65192562019-05-21 Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion Castle, Paige E. Scheven, Ulrich M. Crouch, A. Colleen Cao, Amos A. Goergen, Craig J. Greve, Joan M. J Magn Reson Imaging Original Research BACKGROUND: One of the primary biomechanical factors influencing arterial health is their deformation across the cardiac cycle, or cyclic strain, which is often associated with arterial stiffness. Deleterious changes in the cardiovascular system, e.g., increased arterial stiffness, can remain undetected until the system is challenged, such as under a cardiac stressor like dobutamine. PURPOSE: To quantify cyclic strain in mice at different locations along the arterial tree prior to and during dobutamine infusion, while evaluating the effects of sex and age. STUDY TYPE: Control/cohort study. ANIMAL MODEL: Twenty C57BL/6 mice; male, female; ∼12 and 24 weeks of age; n = 5 per group. FIELD STRENGTH/SEQUENCE: 7T; CINE MRI with 12 frames, velocity compensation, and prospective cardiac gating. ASSESSMENT: Prior to and during the infusion of dobutamine, Green–Lagrange circumferential cyclic strain was calculated from perimeter measurements derived from CINE data acquired at the carotid artery, suprarenal and infrarenal abdominal aorta, and iliac artery. STATISTICAL TESTS: Analysis of variance (ANOVA) followed by post‐hoc tests was used to evaluate the influence of dobutamine, anatomical location, sex, and age. RESULTS: Heart rates did not differ between groups prior to or during dobutamine infusion (P = 0.87 and P = 0.08, respectively). Dobutamine increased cyclic strain in each group. Within a group, increases in strain were similar across arteries. At the suprarenal aorta, strain was reduced in older mice at baseline (young 27.6 > mature 19.3%, P = 0.01) and during dobutamine infusion (young 53.0 > mature 36.2%, P = 0.005). In the infrarenal aorta, the response (dobutamine – baseline) was reduced in older mice (young 21.9 > mature 13.5%, P = 0.04). DATA CONCLUSION: Dobutamine infusion increases circumferential cyclic strain throughout the arterial tree of mice. This effect is quantifiable using CINE MRI. The results demonstrate that strain prior to and during dobutamine is influenced by anatomical location, sex, and age. Level of Evidence: 3 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2019;49:69–80. John Wiley and Sons Inc. 2018-10-06 2019-01 /pmc/articles/PMC6519256/ /pubmed/30291650 http://dx.doi.org/10.1002/jmri.26232 Text en © 2018 The Authors. Journal of Magnetic Resonance Imaging published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Castle, Paige E.
Scheven, Ulrich M.
Crouch, A. Colleen
Cao, Amos A.
Goergen, Craig J.
Greve, Joan M.
Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion
title Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion
title_full Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion
title_fullStr Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion
title_full_unstemmed Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion
title_short Anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion
title_sort anatomical location, sex, and age influence murine arterial circumferential cyclic strain before and during dobutamine infusion
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519256/
https://www.ncbi.nlm.nih.gov/pubmed/30291650
http://dx.doi.org/10.1002/jmri.26232
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