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From single cells to tissue self‐organization

Self‐organization is a process by which interacting cells organize and arrange themselves in higher order structures and patterns. To achieve this, cells must have molecular mechanisms to sense their complex local environment and interpret it to respond accordingly. A combination of cell‐intrinsic a...

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Detalles Bibliográficos
Autores principales: Xavier da Silveira dos Santos, Aline, Liberali, Prisca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519261/
https://www.ncbi.nlm.nih.gov/pubmed/30390414
http://dx.doi.org/10.1111/febs.14694
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author Xavier da Silveira dos Santos, Aline
Liberali, Prisca
author_facet Xavier da Silveira dos Santos, Aline
Liberali, Prisca
author_sort Xavier da Silveira dos Santos, Aline
collection PubMed
description Self‐organization is a process by which interacting cells organize and arrange themselves in higher order structures and patterns. To achieve this, cells must have molecular mechanisms to sense their complex local environment and interpret it to respond accordingly. A combination of cell‐intrinsic and cell‐extrinsic cues are decoded by the single cells dictating their behaviour, their differentiation and symmetry‐breaking potential driving development, tissue remodeling and regenerative processes. A unifying property of these self‐organized pattern‐forming systems is the importance of fluctuations, cell‐to‐cell variability, or noise. Cell‐to‐cell variability is an inherent and emergent property of populations of cells that maximize the population performance instead of the individual cell, providing tissues the flexibility to develop and maintain homeostasis in diverse environments. In this review, we will explore the role of self‐organization and cell‐to‐cell variability as fundamental properties of multicellularity—and the requisite of single‐cell resolution for its understanding. Moreover, we will analyze how single cells generate emergent multicellular dynamics observed at the tissue level ‘travelling’ across different scales: spatial, temporal and functional.
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spelling pubmed-65192612019-05-21 From single cells to tissue self‐organization Xavier da Silveira dos Santos, Aline Liberali, Prisca FEBS J Review Articles Self‐organization is a process by which interacting cells organize and arrange themselves in higher order structures and patterns. To achieve this, cells must have molecular mechanisms to sense their complex local environment and interpret it to respond accordingly. A combination of cell‐intrinsic and cell‐extrinsic cues are decoded by the single cells dictating their behaviour, their differentiation and symmetry‐breaking potential driving development, tissue remodeling and regenerative processes. A unifying property of these self‐organized pattern‐forming systems is the importance of fluctuations, cell‐to‐cell variability, or noise. Cell‐to‐cell variability is an inherent and emergent property of populations of cells that maximize the population performance instead of the individual cell, providing tissues the flexibility to develop and maintain homeostasis in diverse environments. In this review, we will explore the role of self‐organization and cell‐to‐cell variability as fundamental properties of multicellularity—and the requisite of single‐cell resolution for its understanding. Moreover, we will analyze how single cells generate emergent multicellular dynamics observed at the tissue level ‘travelling’ across different scales: spatial, temporal and functional. John Wiley and Sons Inc. 2018-11-19 2019-04 /pmc/articles/PMC6519261/ /pubmed/30390414 http://dx.doi.org/10.1111/febs.14694 Text en © 2018 The Authors. The FEBS Journal published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Review Articles
Xavier da Silveira dos Santos, Aline
Liberali, Prisca
From single cells to tissue self‐organization
title From single cells to tissue self‐organization
title_full From single cells to tissue self‐organization
title_fullStr From single cells to tissue self‐organization
title_full_unstemmed From single cells to tissue self‐organization
title_short From single cells to tissue self‐organization
title_sort from single cells to tissue self‐organization
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519261/
https://www.ncbi.nlm.nih.gov/pubmed/30390414
http://dx.doi.org/10.1111/febs.14694
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