Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer

In urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self‐renewal, governed by TERT expression and telomerase activation, is crucial for cancer progression. Thus, telomerase activation through the interplay of mutations (TERTp(Mut)) and epigenetic altera...

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Detalles Bibliográficos
Autores principales: Leão, Ricardo, Lee, Donghyun, Figueiredo, Arnaldo, Hermanns, Thomas, Wild, Peter, Komosa, Martin, Lau, Irene, Mistry, Mathew, Nunes, Nuno Miguel, Price, Aryeh J., Zhang, Cindy, Lipman, Tatiana, Poyet, Cédric, Valtcheva, Nadejda, Oehl, Kathrin, Coelho, Hugo, Sayyid, Rashid, Gomes, Ana Melo, Prado e Castro, Ligia, Sweet, Joan, Vinagre, João, Apolónio, Joana, Stephens, Derek, Faleiro, Inês, Fadaak, Kamel, Richard, Patrick O., Kulkarni, Girish, Zlotta, Alexandre R., Hamilton, Robert J., Castelo‐Branco, Pedro, Tabori, Uri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2018
Materias:
Tumor Markers and Signatures
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519346/
https://www.ncbi.nlm.nih.gov/pubmed/30350309
http://dx.doi.org/10.1002/ijc.31935

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