LINE-1 derepression in senescent cells triggers interferon and inflammaging

Retrotransposable elements (RTEs) are deleterious at multiple levels, and failure of host surveillance systems can thus have negative consequences. However, the contribution of RTE activity to aging and age-associated diseases is not known. Here we show that during cellular senescence LINE-1 element...

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Detalles Bibliográficos
Autores principales: Cecco, Marco De, Ito, Takahiro, Petrashen, Anna P., Elias, Amy E., Skvir, Nicholas J., Criscione, Steven W., Caligiana, Alberto, Brocculi, Greta, Adney, Emily M., Boeke, Jef D., Le, Oanh, Beauséjour, Christian, Ambati, Jayakrishna, Ambati, Kameshwari, Simon, Matthew, Seluanov, Andrei, Gorbunova, Vera, Slagboom, P. Eline, Helfand, Stephen L., Neretti, Nicola, Sedivy, John M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6519963/
https://www.ncbi.nlm.nih.gov/pubmed/30728521
http://dx.doi.org/10.1038/s41586-018-0784-9

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