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Identification of inflammatory and vascular markers associated with mild cognitive impairment

Biochemical processes have been associated with the pathogenesis of mild cognitive impairment (MCI) and dementia, including chronic inflammation, dysregulation of membrane lipids and disruption of neurotransmitter pathways. However, research investigating biomarkers of these processes in MCI remaine...

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Autores principales: Shen, Xue-Ning, Lu, Yanxia, Tan, Crystal Tze Ying, Liu, Ling-Yun, Yu, Jin-Tai, Feng, Lei, Larbi, Anis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520012/
https://www.ncbi.nlm.nih.gov/pubmed/31039131
http://dx.doi.org/10.18632/aging.101924
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author Shen, Xue-Ning
Lu, Yanxia
Tan, Crystal Tze Ying
Liu, Ling-Yun
Yu, Jin-Tai
Feng, Lei
Larbi, Anis
author_facet Shen, Xue-Ning
Lu, Yanxia
Tan, Crystal Tze Ying
Liu, Ling-Yun
Yu, Jin-Tai
Feng, Lei
Larbi, Anis
author_sort Shen, Xue-Ning
collection PubMed
description Biochemical processes have been associated with the pathogenesis of mild cognitive impairment (MCI) and dementia, including chronic inflammation, dysregulation of membrane lipids and disruption of neurotransmitter pathways. However, research investigating biomarkers of these processes in MCI remained sparse and inconsistent. To collect fresh evidence, we evaluated the performance of several potential markers in a cohort of 57 MCI patients and 57 cognitively healthy controls. MCI patients showed obviously increased levels of plasma TNF-α (p = 0.045) and C-peptide (p = 0.004) as well as decreased levels of VEGF-A (p = 0.042) and PAI-1 (p = 0.019), compared with controls. In addition, our study detected significant correlations of plasma sTNFR-1 (MCI + Control: B = -6.529, p = 0.020; MCI: B = -9.865, p = 0.011) and sIL-2Rα (MCI + Control: B = -7.010, p = 0.007; MCI: B = -11.834, p = 0.003) levels with MoCA scores in the whole cohort and the MCI group. These findings corroborate the inflammatory and vascular hypothesis for dementia. Future studies are warranted to determine their potential as early biomarkers for cognitive deficits and explore the related mechanisms.
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spelling pubmed-65200122019-05-29 Identification of inflammatory and vascular markers associated with mild cognitive impairment Shen, Xue-Ning Lu, Yanxia Tan, Crystal Tze Ying Liu, Ling-Yun Yu, Jin-Tai Feng, Lei Larbi, Anis Aging (Albany NY) Research Paper Biochemical processes have been associated with the pathogenesis of mild cognitive impairment (MCI) and dementia, including chronic inflammation, dysregulation of membrane lipids and disruption of neurotransmitter pathways. However, research investigating biomarkers of these processes in MCI remained sparse and inconsistent. To collect fresh evidence, we evaluated the performance of several potential markers in a cohort of 57 MCI patients and 57 cognitively healthy controls. MCI patients showed obviously increased levels of plasma TNF-α (p = 0.045) and C-peptide (p = 0.004) as well as decreased levels of VEGF-A (p = 0.042) and PAI-1 (p = 0.019), compared with controls. In addition, our study detected significant correlations of plasma sTNFR-1 (MCI + Control: B = -6.529, p = 0.020; MCI: B = -9.865, p = 0.011) and sIL-2Rα (MCI + Control: B = -7.010, p = 0.007; MCI: B = -11.834, p = 0.003) levels with MoCA scores in the whole cohort and the MCI group. These findings corroborate the inflammatory and vascular hypothesis for dementia. Future studies are warranted to determine their potential as early biomarkers for cognitive deficits and explore the related mechanisms. Impact Journals 2019-04-30 /pmc/articles/PMC6520012/ /pubmed/31039131 http://dx.doi.org/10.18632/aging.101924 Text en Copyright © 2019 Shen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY) 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Shen, Xue-Ning
Lu, Yanxia
Tan, Crystal Tze Ying
Liu, Ling-Yun
Yu, Jin-Tai
Feng, Lei
Larbi, Anis
Identification of inflammatory and vascular markers associated with mild cognitive impairment
title Identification of inflammatory and vascular markers associated with mild cognitive impairment
title_full Identification of inflammatory and vascular markers associated with mild cognitive impairment
title_fullStr Identification of inflammatory and vascular markers associated with mild cognitive impairment
title_full_unstemmed Identification of inflammatory and vascular markers associated with mild cognitive impairment
title_short Identification of inflammatory and vascular markers associated with mild cognitive impairment
title_sort identification of inflammatory and vascular markers associated with mild cognitive impairment
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520012/
https://www.ncbi.nlm.nih.gov/pubmed/31039131
http://dx.doi.org/10.18632/aging.101924
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