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Genomic SEM Provides Insights into the Multivariate Genetic Architecture of Complex Traits

Genetic correlations estimated from GWAS reveal pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural equation modeling (Genomic SEM), a multivariate method for analyzing the joint genetic architecture of complex traits. Genomic SEM synthesizes genetic correlation...

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Detalles Bibliográficos
Autores principales:	Grotzinger, Andrew D., Rhemtulla, Mijke, de Vlaming, Ronald, Ritchie, Stuart J., Mallard, Travis T., Hill, W. David, Ip, Hill F., Marioni, Riccardo E., McIntosh, Andrew M., Deary, Ian J., Koellinger, Philipp D., Harden, K. Paige, Nivard, Michel G., Tucker-Drob, Elliot M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520146/ https://www.ncbi.nlm.nih.gov/pubmed/30962613 http://dx.doi.org/10.1038/s41562-019-0566-x

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