Antidiabetic and cardiovascular beneficial effects of a liver-localized mitochondrial uncoupler

Inducing mitochondrial uncoupling (mUncoupling) is an attractive therapeutic strategy for treating metabolic diseases because it leads to calorie-wasting by reducing the efficiency of oxidative phosphorylation (OXPHOS) in mitochondria. Here we report a safe mUncoupler, OPC-163493, which has unique p...

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Detalles Bibliográficos
Autores principales: Kanemoto, Naohide, Okamoto, Takashi, Tanabe, Koji, Shimada, Takahiro, Minoshima, Hitomi, Hidoh, Yuya, Aoyama, Masashi, Ban, Takashi, Kobayashi, Yusuke, Ando, Hikaru, Inoue, Yuki, Itotani, Motohiro, Sato, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520346/
https://www.ncbi.nlm.nih.gov/pubmed/31092829
http://dx.doi.org/10.1038/s41467-019-09911-6

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