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Insulin prevents and reverts simvastatin-induced toxicity in C2C12 skeletal muscle cells

Simvastatin is an inhibitor of the 3-hydroxy-3-methylglutaryl-CoA reductase used for decreasing low density lipoprotein (LDL)-cholesterol in patients. It is well-tolerated but can cause myopathy. Our aims were to enlarge our knowledge regarding mechanisms and effects of insulin on simvastatin-associ...

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Detalles Bibliográficos
Autores principales:	Sanvee, Gerda M., Bouitbir, Jamal, Krähenbühl, Stephan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520350/ https://www.ncbi.nlm.nih.gov/pubmed/31092879 http://dx.doi.org/10.1038/s41598-019-43938-5

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