Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein

The human protein tyrosine phosphatase non-receptor type 3 (PTPN3) is a PDZ (PSD-95/Dlg/ZO-1) domain-containing phosphatase with a tumor-suppressive or a tumor-promoting role in many cancers. Interestingly, the high-risk genital human papillomavirus (HPV) types 16 and 18 target the PDZ domain of PTP...

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Detalles Bibliográficos
Autores principales: Genera, Mariano, Samson, Damien, Raynal, Bertrand, Haouz, Ahmed, Baron, Bruno, Simenel, Catherine, Guerois, Raphael, Wolff, Nicolas, Caillet-Saguy, Célia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520365/
https://www.ncbi.nlm.nih.gov/pubmed/31092861
http://dx.doi.org/10.1038/s41598-019-43932-x

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