CRISPR-Cas9 Screening of Kaposi’s Sarcoma-Associated Herpesvirus-Transformed Cells Identifies XPO1 as a Vulnerable Target of Cancer Cells

The abnormal proliferation of cancer cells is driven by deregulated oncogenes or tumor suppressors, among which the cancer-vulnerable genes are attractive therapeutic targets. Targeting mislocalization of oncogenes and tumor suppressors resulting from aberrant nuclear export is effective for inhibit...

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Detalles Bibliográficos
Autores principales: Gruffaz, Marion, Yuan, Hongfeng, Meng, Wen, Liu, Hui, Bae, Sangsu, Kim, Jin-Soo, Lu, Chun, Huang, Yufei, Gao, Shou-Jiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520457/
https://www.ncbi.nlm.nih.gov/pubmed/31088931
http://dx.doi.org/10.1128/mBio.00866-19

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