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A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale

OBJECTIVE: In recent years, increasing attention has been paid to cryptogenic stroke (CS) caused by the patent foramen ovale (PFO). This study aims to compare contrast transthoracic echocardiography (cTTE) and contrast transcranial Doppler (cTCD) to determine whether cTTE is more suitable and reliab...

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Autores principales: Chen, Jie, Chen, Luyun, Hu, Wangwang, Ni, Xianda, Zhang, Zengrui, Feng, Xiaowen, Fan, Zijian, Chen, Cuiping, Qiu, Fengzhen, Shao, Bei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520470/
https://www.ncbi.nlm.nih.gov/pubmed/30941931
http://dx.doi.org/10.1002/brb3.1283
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author Chen, Jie
Chen, Luyun
Hu, Wangwang
Ni, Xianda
Zhang, Zengrui
Feng, Xiaowen
Fan, Zijian
Chen, Cuiping
Qiu, Fengzhen
Shao, Bei
author_facet Chen, Jie
Chen, Luyun
Hu, Wangwang
Ni, Xianda
Zhang, Zengrui
Feng, Xiaowen
Fan, Zijian
Chen, Cuiping
Qiu, Fengzhen
Shao, Bei
author_sort Chen, Jie
collection PubMed
description OBJECTIVE: In recent years, increasing attention has been paid to cryptogenic stroke (CS) caused by the patent foramen ovale (PFO). This study aims to compare contrast transthoracic echocardiography (cTTE) and contrast transcranial Doppler (cTCD) to determine whether cTTE is more suitable and reliable than cTCD for clinical use. METHODS: From March 2017 to May 2018, patients who suffered from migraines, stroke, hypomnesis, or asymptomatic stroke found casually were included in our study. Patients with CS were semirandomly divided into two groups (cTTE and cTCD) according to the date of the outpatient visit. Patients with either of the examination above found positive were selected to finish transesophageal echocardiography (TEE). RESULTS: In our study, the sensitivities of group cTTE positive (group cTTE+) and group cTCD positive (group cTCD+) did not have any statistical difference (89% vs. 80%, p = 0.236). Focusing on group cTCD+, we discovered that the semiquantitative shunt grading was not correlated with whether a PFO was present or not (p = 0.194). However, once the PFO has been diagnosed, the shunt grading was shown to be related to the width of the gaps (p = 0.032, p (deviation) = 0.03). CONCLUSION: Both cTTE and the cTCD can be used for preliminary PFO findings. The semiquantitative shunt grading of cTCD and cTTE can suggest the size of the PFO and the next course of treatment. The cTTE may be more significant to a safe PFO (a PFO does not have right‐to‐left shunts, RLSs). Combining cTTE and TEE could help diagnose PFO and assess CS risk.
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spelling pubmed-65204702019-05-23 A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale Chen, Jie Chen, Luyun Hu, Wangwang Ni, Xianda Zhang, Zengrui Feng, Xiaowen Fan, Zijian Chen, Cuiping Qiu, Fengzhen Shao, Bei Brain Behav Original Research OBJECTIVE: In recent years, increasing attention has been paid to cryptogenic stroke (CS) caused by the patent foramen ovale (PFO). This study aims to compare contrast transthoracic echocardiography (cTTE) and contrast transcranial Doppler (cTCD) to determine whether cTTE is more suitable and reliable than cTCD for clinical use. METHODS: From March 2017 to May 2018, patients who suffered from migraines, stroke, hypomnesis, or asymptomatic stroke found casually were included in our study. Patients with CS were semirandomly divided into two groups (cTTE and cTCD) according to the date of the outpatient visit. Patients with either of the examination above found positive were selected to finish transesophageal echocardiography (TEE). RESULTS: In our study, the sensitivities of group cTTE positive (group cTTE+) and group cTCD positive (group cTCD+) did not have any statistical difference (89% vs. 80%, p = 0.236). Focusing on group cTCD+, we discovered that the semiquantitative shunt grading was not correlated with whether a PFO was present or not (p = 0.194). However, once the PFO has been diagnosed, the shunt grading was shown to be related to the width of the gaps (p = 0.032, p (deviation) = 0.03). CONCLUSION: Both cTTE and the cTCD can be used for preliminary PFO findings. The semiquantitative shunt grading of cTCD and cTTE can suggest the size of the PFO and the next course of treatment. The cTTE may be more significant to a safe PFO (a PFO does not have right‐to‐left shunts, RLSs). Combining cTTE and TEE could help diagnose PFO and assess CS risk. John Wiley and Sons Inc. 2019-04-02 /pmc/articles/PMC6520470/ /pubmed/30941931 http://dx.doi.org/10.1002/brb3.1283 Text en © 2019 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Chen, Jie
Chen, Luyun
Hu, Wangwang
Ni, Xianda
Zhang, Zengrui
Feng, Xiaowen
Fan, Zijian
Chen, Cuiping
Qiu, Fengzhen
Shao, Bei
A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale
title A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale
title_full A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale
title_fullStr A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale
title_full_unstemmed A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale
title_short A comparison of contrast transthoracic echocardiography and contrast transcranial Doppler in cryptogenic stroke patients with patent foramen ovale
title_sort comparison of contrast transthoracic echocardiography and contrast transcranial doppler in cryptogenic stroke patients with patent foramen ovale
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520470/
https://www.ncbi.nlm.nih.gov/pubmed/30941931
http://dx.doi.org/10.1002/brb3.1283
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