Degradation of D-2-hydroxyglutarate in the presence of isocitrate dehydrogenase mutations

D-2-Hydroxyglutarate (D-2-HG) is regarded as an oncometabolite. It is found at elevated levels in certain malignancies such as acute myeloid leukaemia and glioma. It is produced by a mutated isocitrate dehydrogenase IDH1/2, a low-affinity/high-capacity enzyme. Its degradation, in contrast, is cataly...

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Detalles Bibliográficos
Autores principales: Berger, Raffaela S., Ellmann, Lisa, Reinders, Joerg, Kreutz, Marina, Stempfl, Thomas, Oefner, Peter J., Dettmer, Katja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520482/
https://www.ncbi.nlm.nih.gov/pubmed/31092874
http://dx.doi.org/10.1038/s41598-019-43891-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520482/
https://www.ncbi.nlm.nih.gov/pubmed/31092874
http://dx.doi.org/10.1038/s41598-019-43891-3

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