Recurrent pregnancy loss: can factor V Leiden mutations be a cause

The role of Factor V Leiden (FVL) mutation in recurrent miscarriages has been disputed. It has been hypothesized that FVL mutation in patients with recurrent miscarriages is treatable. In this study, we evaluated 78 pregnant women for FVL mutations, among whom 50 had a history of recurrent miscarria...

Descripción completa

Detalles Bibliográficos
Autores principales: Reddy, R R N, Mutreja, Deepti, Moorchung, Nikhil, Mukhopadhyay, Indrayani
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2019
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520547/
https://www.ncbi.nlm.nih.gov/pubmed/31139594
http://dx.doi.org/10.5468/ogs.2019.62.3.179
_version_ 1783418758968115200
author Reddy, R R N
Mutreja, Deepti
Moorchung, Nikhil
Mukhopadhyay, Indrayani
author_facet Reddy, R R N
Mutreja, Deepti
Moorchung, Nikhil
Mukhopadhyay, Indrayani
author_sort Reddy, R R N
collection PubMed
description The role of Factor V Leiden (FVL) mutation in recurrent miscarriages has been disputed. It has been hypothesized that FVL mutation in patients with recurrent miscarriages is treatable. In this study, we evaluated 78 pregnant women for FVL mutations, among whom 50 had a history of recurrent miscarriages. Only 1 (2%) of the woman was positive for heterozygous FVL mutation. The incidence of FVL mutations in patients with recurrent pregnancy loss had an odds ratio of 1.72 (95% confidence interval, 0.0681–43.8257; P>0.05). However, the findings were not statistically significant. Thus, we suggest that FVL mutation study may not be included in the battery of tests for recurrent miscarriages in the Indian population.
format Online
Article
Text
id pubmed-6520547
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society
record_format MEDLINE/PubMed
spelling pubmed-65205472019-05-28 Recurrent pregnancy loss: can factor V Leiden mutations be a cause Reddy, R R N Mutreja, Deepti Moorchung, Nikhil Mukhopadhyay, Indrayani Obstet Gynecol Sci Short Communication The role of Factor V Leiden (FVL) mutation in recurrent miscarriages has been disputed. It has been hypothesized that FVL mutation in patients with recurrent miscarriages is treatable. In this study, we evaluated 78 pregnant women for FVL mutations, among whom 50 had a history of recurrent miscarriages. Only 1 (2%) of the woman was positive for heterozygous FVL mutation. The incidence of FVL mutations in patients with recurrent pregnancy loss had an odds ratio of 1.72 (95% confidence interval, 0.0681–43.8257; P>0.05). However, the findings were not statistically significant. Thus, we suggest that FVL mutation study may not be included in the battery of tests for recurrent miscarriages in the Indian population. Korean Society of Obstetrics and Gynecology; Korean Society of Contraception and Reproductive Health; Korean Society of Gynecologic Endocrinology; Korean Society of Gynecologic Endoscopy and Minimal Invasive Surgery; Korean Society of Maternal Fetal Medicine; Korean Society of Ultrasound in Obstetrics and Gynecology; Korean Urogynecologic Society 2019-05 2019-04-22 /pmc/articles/PMC6520547/ /pubmed/31139594 http://dx.doi.org/10.5468/ogs.2019.62.3.179 Text en Copyright © 2019 Korean Society of Obstetrics and Gynecology http://creativecommons.org/licenses/by-nc/3.0/ Articles published in Obstet Gynecol Sci are open-access, distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Short Communication
Reddy, R R N
Mutreja, Deepti
Moorchung, Nikhil
Mukhopadhyay, Indrayani
Recurrent pregnancy loss: can factor V Leiden mutations be a cause
title Recurrent pregnancy loss: can factor V Leiden mutations be a cause
title_full Recurrent pregnancy loss: can factor V Leiden mutations be a cause
title_fullStr Recurrent pregnancy loss: can factor V Leiden mutations be a cause
title_full_unstemmed Recurrent pregnancy loss: can factor V Leiden mutations be a cause
title_short Recurrent pregnancy loss: can factor V Leiden mutations be a cause
title_sort recurrent pregnancy loss: can factor v leiden mutations be a cause
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520547/
https://www.ncbi.nlm.nih.gov/pubmed/31139594
http://dx.doi.org/10.5468/ogs.2019.62.3.179
work_keys_str_mv AT reddyrrn recurrentpregnancylosscanfactorvleidenmutationsbeacause
AT mutrejadeepti recurrentpregnancylosscanfactorvleidenmutationsbeacause
AT moorchungnikhil recurrentpregnancylosscanfactorvleidenmutationsbeacause
AT mukhopadhyayindrayani recurrentpregnancylosscanfactorvleidenmutationsbeacause

Ejemplares similares