Evolution of Resistance in Cancer: A Cell Cycle Perspective

Resistance of neoplastic cells to therapy is considered a key challenge in the treatment of cancer. Emergence of resistance is commonly attributed to the gradual mutational evolution of neoplastic cells. However, accumulating evidence suggests that exogenous stressors could significantly accelerate...

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Detalles Bibliográficos
Autores principales: Dökümcü, Kağan, Farahani, Ramin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520611/
https://www.ncbi.nlm.nih.gov/pubmed/31143706
http://dx.doi.org/10.3389/fonc.2019.00376
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author Dökümcü, Kağan
Farahani, Ramin M.
author_facet Dökümcü, Kağan
Farahani, Ramin M.
author_sort Dökümcü, Kağan
collection PubMed
description Resistance of neoplastic cells to therapy is considered a key challenge in the treatment of cancer. Emergence of resistance is commonly attributed to the gradual mutational evolution of neoplastic cells. However, accumulating evidence suggests that exogenous stressors could significantly accelerate the emergence of resistant clones during the course of treatment. Herein, we review molecular mechanisms that regulate the evolution of resistance in a tumor with particular emphasis on the role of cell cycle.
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spelling pubmed-65206112019-05-29 Evolution of Resistance in Cancer: A Cell Cycle Perspective Dökümcü, Kağan Farahani, Ramin M. Front Oncol Oncology Resistance of neoplastic cells to therapy is considered a key challenge in the treatment of cancer. Emergence of resistance is commonly attributed to the gradual mutational evolution of neoplastic cells. However, accumulating evidence suggests that exogenous stressors could significantly accelerate the emergence of resistant clones during the course of treatment. Herein, we review molecular mechanisms that regulate the evolution of resistance in a tumor with particular emphasis on the role of cell cycle. Frontiers Media S.A. 2019-05-09 /pmc/articles/PMC6520611/ /pubmed/31143706 http://dx.doi.org/10.3389/fonc.2019.00376 Text en Copyright © 2019 Dökümcü and Farahani. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Dökümcü, Kağan
Farahani, Ramin M.
Evolution of Resistance in Cancer: A Cell Cycle Perspective
title Evolution of Resistance in Cancer: A Cell Cycle Perspective
title_full Evolution of Resistance in Cancer: A Cell Cycle Perspective
title_fullStr Evolution of Resistance in Cancer: A Cell Cycle Perspective
title_full_unstemmed Evolution of Resistance in Cancer: A Cell Cycle Perspective
title_short Evolution of Resistance in Cancer: A Cell Cycle Perspective
title_sort evolution of resistance in cancer: a cell cycle perspective
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520611/
https://www.ncbi.nlm.nih.gov/pubmed/31143706
http://dx.doi.org/10.3389/fonc.2019.00376
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