Senescent Hepatocytes in Decompensated Liver Show Reduced UPR(MT) and Its Key Player, CLPP, Attenuates Senescence In Vitro

BACKGROUND AND AIMS: Non-dividing hepatocytes in end-stage liver disease indicates permanent growth arrest similar to senescence. Identifying senescence in vivo is often challenging and mechanisms inhibiting senescence are poorly understood. In lower organisms mitochondrial unfolded protein response...

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Detalles Bibliográficos
Autores principales: Sen, Bijoya, Rastogi, Archana, Nath, Rhisita, Shasthry, Saggere M., Pamecha, Viniyendra, Pandey, Sonika, Gupta, Kapuganti Jagadis, Sarin, Shiv K., Trehanpati, Nirupma, Ramakrishna, Gayatri
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520637/
https://www.ncbi.nlm.nih.gov/pubmed/30878663
http://dx.doi.org/10.1016/j.jcmgh.2019.03.001

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