Cargando…

Differential Regulation of Syngap1 Translation by FMRP Modulates eEF2 Mediated Response on NMDAR Activity

SYNGAP1, a Synaptic Ras-GTPase activating protein, regulates synapse maturation during a critical developmental window. Heterozygous mutation in SYNGAP1 (SYNGAP1(-/+)) has been shown to cause Intellectual Disability (ID) in children. Recent studies have provided evidence for altered neuronal protein...

Descripción completa

Detalles Bibliográficos
Autores principales:	Paul, Abhik, Nawalpuri, Bharti, Shah, Devanshi, Sateesh, Shruthi, Muddashetty, Ravi S., Clement, James P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2019
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520660/ https://www.ncbi.nlm.nih.gov/pubmed/31143100 http://dx.doi.org/10.3389/fnmol.2019.00097

Ejemplares similares

NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP
por: Kute, Preeti Madhav, et al.
Publicado: (2019)

NMDAR mediated dynamic changes in m(6)A inversely correlates with neuronal translation
por: Gowda, Naveen Kumar Chandappa, et al.
Publicado: (2022)

The Role of Dynamic miRISC During Neuronal Development
por: Nawalpuri, Bharti, et al.
Publicado: (2020)

Novel regulation of the eEF2K/eEF2 pathway: prospects of ‘PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation’
por: Shen, Yuqian, et al.
Publicado: (2021)

Characterisation of Translation Elongation Factor eEF1B Subunit Expression in Mammalian Cells and Tissues and Co-Localisation with eEF1A2
por: Cao, Yuan, et al.
Publicado: (2014)

Ribosomal stress activates eEF2K–eEF2 pathway causing translation elongation inhibition and recruitment of Terminal Oligopyrimidine (TOP) mRNAs on polysomes
por: Gismondi, Angelo, et al.
Publicado: (2014)

Coordination of changes in expression and phosphorylation of eukaryotic elongation factor 2 (eEF2) and eEF2 kinase in hypertrophied cardiomyocytes
por: Kameshima, Satoshi, et al.
Publicado: (2016)

Rpl24(Bst) mutation suppresses colorectal cancer by promoting eEF2 phosphorylation via eEF2K
por: Knight, John RP, et al.
Publicado: (2021)

On the Need to Tell Apart Fraternal Twins eEF1A1 and eEF1A2, and Their Respective Outfits
por: Mills, Alberto, et al.
Publicado: (2021)

Non-translational Connections of eEF1B in the Cytoplasm and Nucleus of Cancer Cells
por: Negrutskii, Boris
Publicado: (2020)

Analysis of the Expression and Subcellular Distribution of eEF1A1 and eEF1A2 mRNAs during Neurodevelopment
por: Wefers, Zoe, et al.
Publicado: (2022)

Highly homologous eEF1A1 and eEF1A2 exhibit differential post-translational modification with significant enrichment around localised sites of sequence variation
por: Soares, Dinesh C, et al.
Publicado: (2013)

SIRT1 Protects the Heart from ER Stress-Induced Injury by Promoting eEF2K/eEF2-Dependent Autophagy
por: Pires Da Silva, Julie, et al.
Publicado: (2020)

Ghrelin rapidly elevates protein synthesis in vitro by employing the rpS6K-eEF2K-eEF2 signalling axis
por: Zhdanov, Alexander V., et al.
Publicado: (2022)

A conserved PUF/Ago/eEF1A complex attenuates translation elongation
por: Friend, Kyle, et al.
Publicado: (2012)

The alphavirus nonstructural protein 2 NTPase induces a host translational shut-off through phosphorylation of eEF2 via cAMP-PKA-eEF2K signaling
por: Treffers, Emmely E., et al.
Publicado: (2023)

Electroacupuncture Improves Synaptic Function in SAMP8 Mice Probably via Inhibition of the AMPK/eEF2K/eEF2 Signaling Pathway
por: Dong, Weiguo, et al.
Publicado: (2019)

A functional eEF2K-eEF2 pathway in the NAc is critical for the expression of cocaine-induced psychomotor sensitisation and conditioned place preference
por: Beiser, Tehila, et al.
Publicado: (2022)

High eEF1A1 Protein Levels Mark Aggressive Prostate Cancers and the In Vitro Targeting of eEF1A1 Reveals the eEF1A1–actin Complex as a New Potential Target for Therapy
por: Bosutti, Alessandra, et al.
Publicado: (2022)

Yeast translation elongation factor eEF3 promotes late stages of tRNA translocation
por: Ranjan, Namit, et al.
Publicado: (2021)

Antibody toolkit to investigate eEF1A methylation dynamics in mRNA translation elongation
por: Mealey-Farr, Robert, et al.
Publicado: (2023)

The translation elongation factor eEF1A1 couples transcription to translation during heat shock response
por: Vera, Maria, et al.
Publicado: (2014)

Ribosome profiling analysis of eEF3-depleted Saccharomyces cerevisiae
por: Kasari, Villu, et al.
Publicado: (2019)

Independent overexpression of the subunits of translation elongation factor complex eEF1H in human lung cancer
por: Veremieva, Maryna, et al.
Publicado: (2014)

The elongation factor eEF3 (Yef3) interacts with mRNA in a translation independent manner
por: Samra, Nitzan, et al.
Publicado: (2015)

Identification of proteins involved in transcription/translation (eEF 1A1) as an inhibitor of Bax induced apoptosis
por: Akintade, Damilare D., et al.
Publicado: (2020)

Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles
por: Péladeau, Christine, et al.
Publicado: (2020)

Structural Models of Human eEF1A1 and eEF1A2 Reveal Two Distinct Surface Clusters of Sequence Variation and Potential Differences in Phosphorylation
por: Soares, Dinesh C., et al.
Publicado: (2009)

Dimethylation of eEF1A at Lysine 55 Plays a Key Role in the Regulation of eEF1A2 on Malignant Cell Functions of Acute Myeloid Leukemia
por: Xiao, Shan, et al.
Publicado: (2020)

The eEF1A Proteins: At the Crossroads of Oncogenesis, Apoptosis, and Viral Infections
por: Abbas, Wasim, et al.
Publicado: (2015)

Eukaryotic Elongation Factor 2 Kinase (eEF2K) in Cancer
por: Wang, Xuemin, et al.
Publicado: (2017)

MLIF Modulates Microglia Polarization in Ischemic Stroke by Targeting eEF1A1
por: Liu, Yulan, et al.
Publicado: (2021)

The translation elongation factor eEF2 is a novel tumor-associated antigen overexpressed in various types of cancers
por: OJI, YUSUKE, et al.
Publicado: (2014)

Cross Talk between eIF2α and eEF2 Phosphorylation Pathways Optimizes Translational Arrest in Response to Oxidative Stress
por: Sanchez, Marisa, et al.
Publicado: (2019)

Elongation factor eEF1B modulates functions of the release factors eRF1 and eRF3 and the efficiency of translation termination in yeast
por: Valouev, Igor A, et al.
Publicado: (2009)

SYNGAP1: Mind the Gap
por: Jeyabalan, Nallathambi, et al.
Publicado: (2016)

Post-Training Dephosphorylation of eEF-2 Promotes Protein Synthesis for Memory Consolidation
por: Im, Heh-In, et al.
Publicado: (2009)

The role of protein elongation factor eEF1A2 in ovarian cancer
por: Lee, Jonathan M
Publicado: (2003)

eEF1A Is an S-RNase Binding Factor in Self-Incompatible Solanum chacoense
por: Soulard, Jonathan, et al.
Publicado: (2014)

Translation elongation factor eEF1A2 is a potential oncoprotein that is overexpressed in two-thirds of breast tumours
por: Tomlinson, Victoria AL, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_ntojn2l6o0441ffq6h9ghnoina