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The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting

The influence of meal frequency and timing on health and disease has been a topic of interest for many years. While epidemiological evidence indicates an association between higher meal frequencies and lower disease risk, experimental trials have shown conflicting results. Furthermore, recent prospe...

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Autores principales: Paoli, Antonio, Tinsley, Grant, Bianco, Antonino, Moro, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520689/
https://www.ncbi.nlm.nih.gov/pubmed/30925707
http://dx.doi.org/10.3390/nu11040719
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author Paoli, Antonio
Tinsley, Grant
Bianco, Antonino
Moro, Tatiana
author_facet Paoli, Antonio
Tinsley, Grant
Bianco, Antonino
Moro, Tatiana
author_sort Paoli, Antonio
collection PubMed
description The influence of meal frequency and timing on health and disease has been a topic of interest for many years. While epidemiological evidence indicates an association between higher meal frequencies and lower disease risk, experimental trials have shown conflicting results. Furthermore, recent prospective research has demonstrated a significant increase in disease risk with a high meal frequency (≥6 meals/day) as compared to a low meal frequency (1–2 meals/day). Apart from meal frequency and timing we also have to consider breakfast consumption and the distribution of daily energy intake, caloric restriction, and night-time eating. A central role in this complex scenario is played by the fasting period length between two meals. The physiological underpinning of these interconnected variables may be through internal circadian clocks, and food consumption that is asynchronous with natural circadian rhythms may exert adverse health effects and increase disease risk. Additionally, alterations in meal frequency and meal timing have the potential to influence energy and macronutrient intake.A regular meal pattern including breakfast consumption, consuming a higher proportion of energy early in the day, reduced meal frequency (i.e., 2–3 meals/day), and regular fasting periods may provide physiological benefits such as reduced inflammation, improved circadian rhythmicity, increased autophagy and stress resistance, and modulation of the gut microbiota
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spelling pubmed-65206892019-05-31 The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting Paoli, Antonio Tinsley, Grant Bianco, Antonino Moro, Tatiana Nutrients Review The influence of meal frequency and timing on health and disease has been a topic of interest for many years. While epidemiological evidence indicates an association between higher meal frequencies and lower disease risk, experimental trials have shown conflicting results. Furthermore, recent prospective research has demonstrated a significant increase in disease risk with a high meal frequency (≥6 meals/day) as compared to a low meal frequency (1–2 meals/day). Apart from meal frequency and timing we also have to consider breakfast consumption and the distribution of daily energy intake, caloric restriction, and night-time eating. A central role in this complex scenario is played by the fasting period length between two meals. The physiological underpinning of these interconnected variables may be through internal circadian clocks, and food consumption that is asynchronous with natural circadian rhythms may exert adverse health effects and increase disease risk. Additionally, alterations in meal frequency and meal timing have the potential to influence energy and macronutrient intake.A regular meal pattern including breakfast consumption, consuming a higher proportion of energy early in the day, reduced meal frequency (i.e., 2–3 meals/day), and regular fasting periods may provide physiological benefits such as reduced inflammation, improved circadian rhythmicity, increased autophagy and stress resistance, and modulation of the gut microbiota MDPI 2019-03-28 /pmc/articles/PMC6520689/ /pubmed/30925707 http://dx.doi.org/10.3390/nu11040719 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Paoli, Antonio
Tinsley, Grant
Bianco, Antonino
Moro, Tatiana
The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
title The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
title_full The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
title_fullStr The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
title_full_unstemmed The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
title_short The Influence of Meal Frequency and Timing on Health in Humans: The Role of Fasting
title_sort influence of meal frequency and timing on health in humans: the role of fasting
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520689/
https://www.ncbi.nlm.nih.gov/pubmed/30925707
http://dx.doi.org/10.3390/nu11040719
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