New Furanocembranoids from Briareum violaceum

Three new furanocembranoids—briaviodiol F (1) and briaviotriols A (2) and B (3)—along with a known analogue, briaviodiol A (4), were obtained from a cultured-type octocoral Briareum violaceum. The structures of cembranoids 1–3 were elucidated by using spectroscopic methods. In vitro study demonstrat...

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Detalles Bibliográficos
Autores principales: Huang, Pin-Chang, Lin, Wen-Sou, Peng, Bo-Rong, Chang, Yu-Chia, Fang, Lee-Shing, Li, Guo-Qiang, Hwang, Tsong-Long, Wen, Zhi-Hong, Sung, Ping-Jyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520705/
https://www.ncbi.nlm.nih.gov/pubmed/30959843
http://dx.doi.org/10.3390/md17040214
Descripción
Sumario:Three new furanocembranoids—briaviodiol F (1) and briaviotriols A (2) and B (3)—along with a known analogue, briaviodiol A (4), were obtained from a cultured-type octocoral Briareum violaceum. The structures of cembranoids 1–3 were elucidated by using spectroscopic methods. In vitro study demonstrated that compounds 2 and 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) release from RAW 264.7, a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.

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