Cargando…

Chronic Treatment with Multi-Kinase Inhibitors Causes Differential Toxicities on Skeletal and Cardiac Muscles

Despite recent progress, chemotherapy remains the preferred treatment for cancer. We have shown a link between anticancer drugs and the development of cachexia, i.e., body wasting accompanied by muscle loss. The multi-kinase inhibitors (MKIs) regorafenib and sorafenib, used as second-line treatment...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huot, Joshua R., Essex, Alyson L., Gutierrez, Maya, Barreto, Rafael, Wang, Meijing, Waning, David L., Plotkin, Lilian I., Bonetto, Andrea
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520777/ https://www.ncbi.nlm.nih.gov/pubmed/31018508 http://dx.doi.org/10.3390/cancers11040571

Ejemplares similares

miR21 deletion in osteocytes has direct and indirect effects on skeletal muscle in a sex-dimorphic manner in mice
por: Essex, Alyson L., et al.
Publicado: (2022)

Bisphosphonate Treatment Ameliorates Chemotherapy-Induced Bone and Muscle Abnormalities in Young Mice
por: Essex, Alyson L., et al.
Publicado: (2019)

MC38 Tumors Induce Musculoskeletal Defects in Colorectal Cancer
por: Huot, Joshua R., et al.
Publicado: (2021)

Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) R47H Variant Causes Distinct Age‐ and Sex‐Dependent Musculoskeletal Alterations in Mice
por: Essex, Alyson L., et al.
Publicado: (2022)

Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs
por: Barreto, Rafael, et al.
Publicado: (2016)

The Mitochondria-Targeting Agent MitoQ Improves Muscle Atrophy, Weakness and Oxidative Metabolism in C26 Tumor-Bearing Mice
por: Pin, Fabrizio, et al.
Publicado: (2022)

PGC1α overexpression preserves muscle mass and function in cisplatin‐induced cachexia
por: Huot, Joshua R., et al.
Publicado: (2022)

HCT116 colorectal liver metastases exacerbate muscle wasting in a mouse model for the study of colorectal cancer cachexia
por: Huot, Joshua R., et al.
Publicado: (2020)

Age- and sex-dependent role of osteocytic pannexin1 on bone and muscle mass and strength
por: Aguilar-Perez, Alexandra, et al.
Publicado: (2019)

Skeletal muscle toxicity associated with tyrosine kinase inhibitor therapy in patients with chronic myeloid leukemia
por: Janssen, L., et al.
Publicado: (2019)

Sex-specific differences in direct osteoclastic versus indirect osteoblastic effects underlay the low bone mass of Pannexin1 deletion in TRAP-expressing cells in mice
por: Deosthale, Padmini, et al.
Publicado: (2022)

Osteolytic Breast Cancer Causes Skeletal Muscle Weakness in an Immunocompetent Syngeneic Mouse Model
por: Regan, Jenna N., et al.
Publicado: (2017)

ACVR2B antagonism as a countermeasure to multi‐organ perturbations in metastatic colorectal cancer cachexia
por: Huot, Joshua R., et al.
Publicado: (2020)

Preservation of muscle mass as a strategy to reduce the toxic effects of cancer chemotherapy on body composition
por: Pin, Fabrizio, et al.
Publicado: (2018)

Influence of the skeletal muscle index on pharmacokinetics and toxicity of fluorouracil
por: Schmulenson, Eduard, et al.
Publicado: (2022)

STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia
por: Bonetto, Andrea, et al.
Publicado: (2011)

Cancer and Chemotherapy Contribute to Muscle Loss by Activating Common Signaling Pathways
por: Barreto, Rafael, et al.
Publicado: (2016)

Skeletal muscle delimited myopathy and verapamil toxicity in SUR2 mutant mouse models of AIMS
por: McClenaghan, Conor, et al.
Publicado: (2023)

Skeletal Muscle Manifestations and Creatine Kinase in COVID-19
por: Friedman, Sarah A., et al.
Publicado: (2022)

Phytoecdysteroids Do Not Have Anabolic Effects in Skeletal Muscle in Sedentary Aging Mice
por: Lawrence, Marcus M., et al.
Publicado: (2021)

DHEA Treatment Effects on Redox Environment in Skeletal Muscle of Young and Aged Healthy Rats
por: Jacob, Maria H.V.M., et al.
Publicado: (2018)

Loss of REDD1 prevents chemotherapy‐induced muscle atrophy and weakness in mice
por: Hain, Brian A., et al.
Publicado: (2021)

Anserine is expressed in human cardiac and skeletal muscles
por: de Souza Gonçalves, Lívia, et al.
Publicado: (2023)

Multi-scale mechanobiological model for skeletal muscle hypertrophy
por: Villota-Narvaez, Yesid, et al.
Publicado: (2022)

Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle
por: Nuss, Jonathan E., et al.
Publicado: (2009)

An Unnecessary Pain: Using Pharmacogenetics for Statin-related Skeletal Muscle Toxicity
por: Alzghari, Saeed K
Publicado: (2018)

Integrated metabolic models for xenobiotic induced mitochondrial toxicity in skeletal muscle
por: Dott, William, et al.
Publicado: (2017)

Glucocorticoids increase skeletal muscle NF‐κB inducing kinase (NIK): links to muscle atrophy
por: Fry, Christopher S., et al.
Publicado: (2016)

Metabolic Biomarkers for the Early Detection of Cancer Cachexia
por: O’Connell, Thomas M., et al.
Publicado: (2021)

Localization of creatine kinase isoenzymes in myofibrils. I. Chicken skeletal muscle
Publicado: (1977)

TAM kinase signaling is indispensable for proper skeletal muscle regeneration in mice
por: Al-Zaeed, Nour, et al.
Publicado: (2021)

Control of Skeletal Muscle Atrophy Associated to Cancer or Corticosteroids by Ceramide Kinase
por: Pierucci, Federica, et al.
Publicado: (2021)

Can coenzyme Q10 alleviate the toxic effect of fenofibrate on skeletal muscle?
por: El-Bassouny, Dalia R., et al.
Publicado: (2023)

Diet-Induced Obesity Prevents Interstitial Dispersion of Insulin in Skeletal Muscle
por: Kolka, Cathryn M., et al.
Publicado: (2010)

Phosphofructo-1-Kinase Deficiency Leads to a Severe Cardiac and Hematological Disorder in Addition to Skeletal Muscle Glycogenosis
por: García, Miguel, et al.
Publicado: (2009)

Mining frequent patterns for AMP-activated protein kinase regulation on skeletal muscle
por: Chen, Qingfeng, et al.
Publicado: (2006)

Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus
por: Forbes, Sean C., et al.
Publicado: (2014)

Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity
por: Nixon, Mark, et al.
Publicado: (2015)

The effect of exercise-intensity on skeletal muscle stress kinase and insulin protein signaling
por: Parker, Lewan, et al.
Publicado: (2017)

Pim1 kinase positively regulates myoblast behaviors and skeletal muscle regeneration
por: Liu, Yuantong, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_dfddtc0j0uhclbjab043h446ut