Influence of the HDAC Inhibitor Valproic Acid on the Growth and Proliferation of Temsirolimus-Resistant Prostate Cancer Cells In Vitro

The mechanistic target of rapamycin (mTOR) is elevated in prostate cancer, making this protein attractive for tumor treatment. Unfortunately, resistance towards mTOR inhibitors develops and the tumor becomes reactivated. We determined whether epigenetic modulation by the histone deacetylase (HDAC) i...

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Detalles Bibliográficos
Autores principales: Makarević, Jasmina, Rutz, Jochen, Juengel, Eva, Maxeiner, Sebastian, Tsaur, Igor, Chun, Felix K.-H., Bereiter-Hahn, Jürgen, Blaheta, Roman A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520872/
https://www.ncbi.nlm.nih.gov/pubmed/31010254
http://dx.doi.org/10.3390/cancers11040566

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520872/
https://www.ncbi.nlm.nih.gov/pubmed/31010254
http://dx.doi.org/10.3390/cancers11040566

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