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Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa
Ebola virus (EBOV) infection is characterized by an excessive inflammatory response, a loss of lymphocytes and a general paralysis of the immune system, however pathophysiological mechanisms are not fully understood. In a cohort of 23 fatal and 21 survivors of ebola virus disease (EVD) cases admitte...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520887/ https://www.ncbi.nlm.nih.gov/pubmed/31018522 http://dx.doi.org/10.3390/v11040373 |
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author | Colavita, Francesca Biava, Mirella Castilletti, Concetta Lanini, Simone Miccio, Rossella Portella, Gina Vairo, Francesco Ippolito, Giuseppe Capobianchi, Maria Rosaria Di Caro, Antonino Lalle, Eleonora |
author_facet | Colavita, Francesca Biava, Mirella Castilletti, Concetta Lanini, Simone Miccio, Rossella Portella, Gina Vairo, Francesco Ippolito, Giuseppe Capobianchi, Maria Rosaria Di Caro, Antonino Lalle, Eleonora |
author_sort | Colavita, Francesca |
collection | PubMed |
description | Ebola virus (EBOV) infection is characterized by an excessive inflammatory response, a loss of lymphocytes and a general paralysis of the immune system, however pathophysiological mechanisms are not fully understood. In a cohort of 23 fatal and 21 survivors of ebola virus disease (EVD) cases admitted to the Emergency Ebola-Treatment-Center in Goderich (Freetown, Sierra Leone) during the 2014 to 2016 EBOV epidemic in Western Africa, we analyzed the pathway-focused gene expression profile of secreted proteins involved in the immune response and the levels of specific anti-EBOV IgM and IgG from the time of admission till discharge or death. We observed a dysregulated inflammatory response in fatal patients as compared to survivors, mainly consisting of the upregulation of inflammatory mediators, whose extent directly correlated with viremia levels. The upregulation persisted and intensified during the late phase of infection. Relevant differences were also found in humoral immunity, as an earlier and more robust EBOV antibody response was observed in survivor patients. |
format | Online Article Text |
id | pubmed-6520887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65208872019-06-03 Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa Colavita, Francesca Biava, Mirella Castilletti, Concetta Lanini, Simone Miccio, Rossella Portella, Gina Vairo, Francesco Ippolito, Giuseppe Capobianchi, Maria Rosaria Di Caro, Antonino Lalle, Eleonora Viruses Article Ebola virus (EBOV) infection is characterized by an excessive inflammatory response, a loss of lymphocytes and a general paralysis of the immune system, however pathophysiological mechanisms are not fully understood. In a cohort of 23 fatal and 21 survivors of ebola virus disease (EVD) cases admitted to the Emergency Ebola-Treatment-Center in Goderich (Freetown, Sierra Leone) during the 2014 to 2016 EBOV epidemic in Western Africa, we analyzed the pathway-focused gene expression profile of secreted proteins involved in the immune response and the levels of specific anti-EBOV IgM and IgG from the time of admission till discharge or death. We observed a dysregulated inflammatory response in fatal patients as compared to survivors, mainly consisting of the upregulation of inflammatory mediators, whose extent directly correlated with viremia levels. The upregulation persisted and intensified during the late phase of infection. Relevant differences were also found in humoral immunity, as an earlier and more robust EBOV antibody response was observed in survivor patients. MDPI 2019-04-23 /pmc/articles/PMC6520887/ /pubmed/31018522 http://dx.doi.org/10.3390/v11040373 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Colavita, Francesca Biava, Mirella Castilletti, Concetta Lanini, Simone Miccio, Rossella Portella, Gina Vairo, Francesco Ippolito, Giuseppe Capobianchi, Maria Rosaria Di Caro, Antonino Lalle, Eleonora Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa |
title | Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa |
title_full | Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa |
title_fullStr | Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa |
title_full_unstemmed | Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa |
title_short | Inflammatory and Humoral Immune Response during Ebola Virus Infection in Survivor and Fatal Cases Occurred in Sierra Leone during the 2014–2016 Outbreak in West Africa |
title_sort | inflammatory and humoral immune response during ebola virus infection in survivor and fatal cases occurred in sierra leone during the 2014–2016 outbreak in west africa |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520887/ https://www.ncbi.nlm.nih.gov/pubmed/31018522 http://dx.doi.org/10.3390/v11040373 |
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