Cargando…
Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence
The effect of low serum 25(OH)D on cognitive function is difficult to determine owing to the many factors that can influence these relationships (e.g., measurements, study design, and obesity). The primary purpose of this review was to synthesize the current evidence on the association between serum...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520924/ https://www.ncbi.nlm.nih.gov/pubmed/30934861 http://dx.doi.org/10.3390/nu11040729 |
_version_ | 1783418841061130240 |
---|---|
author | Byrn, Mary A. Sheean, Patricia M. |
author_facet | Byrn, Mary A. Sheean, Patricia M. |
author_sort | Byrn, Mary A. |
collection | PubMed |
description | The effect of low serum 25(OH)D on cognitive function is difficult to determine owing to the many factors that can influence these relationships (e.g., measurements, study design, and obesity). The primary purpose of this review was to synthesize the current evidence on the association between serum 25(OH)D and cognition giving special consideration to specific influential factors. A search was conducted in PubMed for studies published between 2010 and 2018 using terms related to serum 25(OH)D and cognition. Only studies that used liquid chromatography tandem-mass spectrometry (LC-MS) were included, since this is considered the ‘gold standard method’, to measure serum 25(OH)D. Of the 70 articles evaluated, 13 met all inclusion criteria for this review. The majority of the observational and longitudinal studies demonstrate a significant association between low serum 25(OH)D and compromised cognition. However, two randomized controlled trials showed inconsistent results on the impact of vitamin D supplementation on cognitive function. The varied methodologies for ascertaining cognition and the inclusion or exclusion of confounding variables (e.g., obesity, sunlight exposure) in the statistical analyses make drawing conclusions on the association between serum 25(OH)D and cognitive functioning inherently difficult. Despite the known higher occurrence of serum 25(OH) deficiency among minority populations, the majority of studies were conducted in with White participants. In order to more clearly discern the relationship between serum 25(OH)D and cognitive functioning, future studies should target more diverse study populations and utilize comprehensive measures to reliably capture cognition, as well as important known determinants of serum 25(OH)D. |
format | Online Article Text |
id | pubmed-6520924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65209242019-05-31 Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence Byrn, Mary A. Sheean, Patricia M. Nutrients Review The effect of low serum 25(OH)D on cognitive function is difficult to determine owing to the many factors that can influence these relationships (e.g., measurements, study design, and obesity). The primary purpose of this review was to synthesize the current evidence on the association between serum 25(OH)D and cognition giving special consideration to specific influential factors. A search was conducted in PubMed for studies published between 2010 and 2018 using terms related to serum 25(OH)D and cognition. Only studies that used liquid chromatography tandem-mass spectrometry (LC-MS) were included, since this is considered the ‘gold standard method’, to measure serum 25(OH)D. Of the 70 articles evaluated, 13 met all inclusion criteria for this review. The majority of the observational and longitudinal studies demonstrate a significant association between low serum 25(OH)D and compromised cognition. However, two randomized controlled trials showed inconsistent results on the impact of vitamin D supplementation on cognitive function. The varied methodologies for ascertaining cognition and the inclusion or exclusion of confounding variables (e.g., obesity, sunlight exposure) in the statistical analyses make drawing conclusions on the association between serum 25(OH)D and cognitive functioning inherently difficult. Despite the known higher occurrence of serum 25(OH) deficiency among minority populations, the majority of studies were conducted in with White participants. In order to more clearly discern the relationship between serum 25(OH)D and cognitive functioning, future studies should target more diverse study populations and utilize comprehensive measures to reliably capture cognition, as well as important known determinants of serum 25(OH)D. MDPI 2019-03-29 /pmc/articles/PMC6520924/ /pubmed/30934861 http://dx.doi.org/10.3390/nu11040729 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Byrn, Mary A. Sheean, Patricia M. Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence |
title | Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence |
title_full | Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence |
title_fullStr | Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence |
title_full_unstemmed | Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence |
title_short | Serum 25(OH)D and Cognition: A Narrative Review of Current Evidence |
title_sort | serum 25(oh)d and cognition: a narrative review of current evidence |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520924/ https://www.ncbi.nlm.nih.gov/pubmed/30934861 http://dx.doi.org/10.3390/nu11040729 |
work_keys_str_mv | AT byrnmarya serum25ohdandcognitionanarrativereviewofcurrentevidence AT sheeanpatriciam serum25ohdandcognitionanarrativereviewofcurrentevidence |