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Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell m...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Royal Society of Chemistry
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520929/ https://www.ncbi.nlm.nih.gov/pubmed/31183034 http://dx.doi.org/10.1039/c9sc00324j |
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author | Lu, Guihong Lv, Chengliang Bao, Weier Li, Feng Zhang, Fan Zhang, Lijun Wang, Shuang Gao, Xiaoyong Zhao, Dongxu Wei, Wei Xie, Hai-yan |
author_facet | Lu, Guihong Lv, Chengliang Bao, Weier Li, Feng Zhang, Fan Zhang, Lijun Wang, Shuang Gao, Xiaoyong Zhao, Dongxu Wei, Wei Xie, Hai-yan |
author_sort | Lu, Guihong |
collection | PubMed |
description | Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (∼55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy. |
format | Online Article Text |
id | pubmed-6520929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-65209292019-06-10 Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics Lu, Guihong Lv, Chengliang Bao, Weier Li, Feng Zhang, Fan Zhang, Lijun Wang, Shuang Gao, Xiaoyong Zhao, Dongxu Wei, Wei Xie, Hai-yan Chem Sci Chemistry Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (∼55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy. Royal Society of Chemistry 2019-04-02 /pmc/articles/PMC6520929/ /pubmed/31183034 http://dx.doi.org/10.1039/c9sc00324j Text en This journal is © The Royal Society of Chemistry 2019 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0) |
spellingShingle | Chemistry Lu, Guihong Lv, Chengliang Bao, Weier Li, Feng Zhang, Fan Zhang, Lijun Wang, Shuang Gao, Xiaoyong Zhao, Dongxu Wei, Wei Xie, Hai-yan Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics |
title | Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
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title_full | Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
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title_fullStr | Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
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title_full_unstemmed | Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
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title_short | Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
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title_sort | antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520929/ https://www.ncbi.nlm.nih.gov/pubmed/31183034 http://dx.doi.org/10.1039/c9sc00324j |
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