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Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition

Glutamine is a conditionally essential amino acid widely used in sports nutrition, especially because of its immunomodulatory role. Notwithstanding, glutamine plays several other biological functions, such as cell proliferation, energy production, glycogenesis, ammonia buffering, maintenance of the...

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Autores principales: Coqueiro, Audrey Yule, Rogero, Marcelo Macedo, Tirapegui, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520936/
https://www.ncbi.nlm.nih.gov/pubmed/30999561
http://dx.doi.org/10.3390/nu11040863
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author Coqueiro, Audrey Yule
Rogero, Marcelo Macedo
Tirapegui, Julio
author_facet Coqueiro, Audrey Yule
Rogero, Marcelo Macedo
Tirapegui, Julio
author_sort Coqueiro, Audrey Yule
collection PubMed
description Glutamine is a conditionally essential amino acid widely used in sports nutrition, especially because of its immunomodulatory role. Notwithstanding, glutamine plays several other biological functions, such as cell proliferation, energy production, glycogenesis, ammonia buffering, maintenance of the acid-base balance, among others. Thus, this amino acid began to be investigated in sports nutrition beyond its effect on the immune system, attributing to glutamine various properties, such as an anti-fatigue role. Considering that the ergogenic potential of this amino acid is still not completely known, this review aimed to address the main properties by which glutamine could delay fatigue, as well as the effects of glutamine supplementation, alone or associated with other nutrients, on fatigue markers and performance in the context of physical exercise. PubMed database was selected to examine the literature, using the keywords combination “glutamine” and “fatigue”. Fifty-five studies met the inclusion criteria and were evaluated in this integrative literature review. Most of the studies evaluated observed that glutamine supplementation improved some fatigue markers, such as increased glycogen synthesis and reduced ammonia accumulation, but this intervention did not increase physical performance. Thus, despite improving some fatigue parameters, glutamine supplementation seems to have limited effects on performance.
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spelling pubmed-65209362019-05-31 Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition Coqueiro, Audrey Yule Rogero, Marcelo Macedo Tirapegui, Julio Nutrients Review Glutamine is a conditionally essential amino acid widely used in sports nutrition, especially because of its immunomodulatory role. Notwithstanding, glutamine plays several other biological functions, such as cell proliferation, energy production, glycogenesis, ammonia buffering, maintenance of the acid-base balance, among others. Thus, this amino acid began to be investigated in sports nutrition beyond its effect on the immune system, attributing to glutamine various properties, such as an anti-fatigue role. Considering that the ergogenic potential of this amino acid is still not completely known, this review aimed to address the main properties by which glutamine could delay fatigue, as well as the effects of glutamine supplementation, alone or associated with other nutrients, on fatigue markers and performance in the context of physical exercise. PubMed database was selected to examine the literature, using the keywords combination “glutamine” and “fatigue”. Fifty-five studies met the inclusion criteria and were evaluated in this integrative literature review. Most of the studies evaluated observed that glutamine supplementation improved some fatigue markers, such as increased glycogen synthesis and reduced ammonia accumulation, but this intervention did not increase physical performance. Thus, despite improving some fatigue parameters, glutamine supplementation seems to have limited effects on performance. MDPI 2019-04-17 /pmc/articles/PMC6520936/ /pubmed/30999561 http://dx.doi.org/10.3390/nu11040863 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Coqueiro, Audrey Yule
Rogero, Marcelo Macedo
Tirapegui, Julio
Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition
title Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition
title_full Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition
title_fullStr Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition
title_full_unstemmed Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition
title_short Glutamine as an Anti-Fatigue Amino Acid in Sports Nutrition
title_sort glutamine as an anti-fatigue amino acid in sports nutrition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520936/
https://www.ncbi.nlm.nih.gov/pubmed/30999561
http://dx.doi.org/10.3390/nu11040863
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