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Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18
Four new ansamycins, named divergolides T–W (1–4), along with two known analogs were isolated from the fermentation broth of the mangrove-derived actinomycete Streptomyces sp. KFD18. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were determined...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520978/ https://www.ncbi.nlm.nih.gov/pubmed/30978939 http://dx.doi.org/10.3390/md17040219 |
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author | Zhou, Li-Man Kong, Fan-Dong Xie, Qing-Yi Ma, Qing-Yun Hu, Zhong Zhao, You-Xing Luo, Du-Qiang |
author_facet | Zhou, Li-Man Kong, Fan-Dong Xie, Qing-Yi Ma, Qing-Yun Hu, Zhong Zhao, You-Xing Luo, Du-Qiang |
author_sort | Zhou, Li-Man |
collection | PubMed |
description | Four new ansamycins, named divergolides T–W (1–4), along with two known analogs were isolated from the fermentation broth of the mangrove-derived actinomycete Streptomyces sp. KFD18. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were determined by spectroscopic data and single-crystal X-ray diffraction analysis. Compounds 1–4 showed cytotoxic activity against the human gastric cancer cell line SGC-7901, the human leukemic cell line K562, the HeLa cell line, and the human lung carcinoma cell line A549, with 1 being the most active while compounds 5 and 6 were inactive against all the tested cell lines. Compounds 1 and 3 showed very potent and specific cytotoxic activities (IC(50) 2.8 and 4.7 µM, respectively) against the SGC-7901 cells. Further, the apoptosis-inducing effect of 1 and 3 against SGC-7901 cells was demonstrated by two kinds of staining methods for the first time. |
format | Online Article Text |
id | pubmed-6520978 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-65209782019-06-03 Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18 Zhou, Li-Man Kong, Fan-Dong Xie, Qing-Yi Ma, Qing-Yun Hu, Zhong Zhao, You-Xing Luo, Du-Qiang Mar Drugs Article Four new ansamycins, named divergolides T–W (1–4), along with two known analogs were isolated from the fermentation broth of the mangrove-derived actinomycete Streptomyces sp. KFD18. The structures of the compounds, including the absolute configurations of their stereogenic carbons, were determined by spectroscopic data and single-crystal X-ray diffraction analysis. Compounds 1–4 showed cytotoxic activity against the human gastric cancer cell line SGC-7901, the human leukemic cell line K562, the HeLa cell line, and the human lung carcinoma cell line A549, with 1 being the most active while compounds 5 and 6 were inactive against all the tested cell lines. Compounds 1 and 3 showed very potent and specific cytotoxic activities (IC(50) 2.8 and 4.7 µM, respectively) against the SGC-7901 cells. Further, the apoptosis-inducing effect of 1 and 3 against SGC-7901 cells was demonstrated by two kinds of staining methods for the first time. MDPI 2019-04-11 /pmc/articles/PMC6520978/ /pubmed/30978939 http://dx.doi.org/10.3390/md17040219 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhou, Li-Man Kong, Fan-Dong Xie, Qing-Yi Ma, Qing-Yun Hu, Zhong Zhao, You-Xing Luo, Du-Qiang Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18 |
title | Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18 |
title_full | Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18 |
title_fullStr | Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18 |
title_full_unstemmed | Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18 |
title_short | Divergolides T–W with Apoptosis-Inducing Activity from the Mangrove-Derived Actinomycete Streptomyces sp. KFD18 |
title_sort | divergolides t–w with apoptosis-inducing activity from the mangrove-derived actinomycete streptomyces sp. kfd18 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520978/ https://www.ncbi.nlm.nih.gov/pubmed/30978939 http://dx.doi.org/10.3390/md17040219 |
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