The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders

Cognitive impairment is strongly associated with functional outcomes in psychiatric patients. Involvement of n-3 long chain polyunsaturated fatty acid (n-3 LC-PUFA), in particular docosahexaenoic acid (DHA), in brain functions is largely documented. DHA is incorporated into membrane phospholipids as...

Descripción completa

Detalles Bibliográficos
Autores principales: Ciappolino, Valentina, Mazzocchi, Alessandra, Botturi, Andrea, Turolo, Stefano, Delvecchio, Giuseppe, Agostoni, Carlo, Brambilla, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520996/
https://www.ncbi.nlm.nih.gov/pubmed/30986970
http://dx.doi.org/10.3390/nu11040769
_version_ 1783418855149797376
author Ciappolino, Valentina
Mazzocchi, Alessandra
Botturi, Andrea
Turolo, Stefano
Delvecchio, Giuseppe
Agostoni, Carlo
Brambilla, Paolo
author_facet Ciappolino, Valentina
Mazzocchi, Alessandra
Botturi, Andrea
Turolo, Stefano
Delvecchio, Giuseppe
Agostoni, Carlo
Brambilla, Paolo
author_sort Ciappolino, Valentina
collection PubMed
description Cognitive impairment is strongly associated with functional outcomes in psychiatric patients. Involvement of n-3 long chain polyunsaturated fatty acid (n-3 LC-PUFA), in particular docosahexaenoic acid (DHA), in brain functions is largely documented. DHA is incorporated into membrane phospholipids as structural component, especially in the central nervous system where it also has important functional effects. The aim of this review is to investigate the relationship between DHA and cognitive function in relation to mental disorders. Results from few randomized controlled trials (RCTs) on the effects of DHA (alone or in combination) in psychotic, mood and neurodevelopmental disorders, respectively, suggest that no conclusive remarks can be drawn.
format Online
Article
Text
id pubmed-6520996
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-65209962019-05-31 The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders Ciappolino, Valentina Mazzocchi, Alessandra Botturi, Andrea Turolo, Stefano Delvecchio, Giuseppe Agostoni, Carlo Brambilla, Paolo Nutrients Review Cognitive impairment is strongly associated with functional outcomes in psychiatric patients. Involvement of n-3 long chain polyunsaturated fatty acid (n-3 LC-PUFA), in particular docosahexaenoic acid (DHA), in brain functions is largely documented. DHA is incorporated into membrane phospholipids as structural component, especially in the central nervous system where it also has important functional effects. The aim of this review is to investigate the relationship between DHA and cognitive function in relation to mental disorders. Results from few randomized controlled trials (RCTs) on the effects of DHA (alone or in combination) in psychotic, mood and neurodevelopmental disorders, respectively, suggest that no conclusive remarks can be drawn. MDPI 2019-04-02 /pmc/articles/PMC6520996/ /pubmed/30986970 http://dx.doi.org/10.3390/nu11040769 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ciappolino, Valentina
Mazzocchi, Alessandra
Botturi, Andrea
Turolo, Stefano
Delvecchio, Giuseppe
Agostoni, Carlo
Brambilla, Paolo
The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders
title The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders
title_full The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders
title_fullStr The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders
title_full_unstemmed The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders
title_short The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders
title_sort role of docosahexaenoic acid (dha) on cognitive functions in psychiatric disorders
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520996/
https://www.ncbi.nlm.nih.gov/pubmed/30986970
http://dx.doi.org/10.3390/nu11040769
work_keys_str_mv AT ciappolinovalentina theroleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT mazzocchialessandra theroleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT botturiandrea theroleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT turolostefano theroleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT delvecchiogiuseppe theroleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT agostonicarlo theroleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT brambillapaolo theroleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT ciappolinovalentina roleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT mazzocchialessandra roleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT botturiandrea roleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT turolostefano roleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT delvecchiogiuseppe roleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT agostonicarlo roleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders
AT brambillapaolo roleofdocosahexaenoicaciddhaoncognitivefunctionsinpsychiatricdisorders

Ejemplares similares